Triclosan

Modify Date: 2024-01-02 12:18:30

Triclosan Structure
Triclosan structure
Common Name Triclosan
CAS Number 3380-34-5 Molecular Weight 289.542
Density 1.5±0.1 g/cm3 Boiling Point 344.6±42.0 °C at 760 mmHg
Molecular Formula C12H7Cl3O2 Melting Point 56-60 °C(lit.)
MSDS Chinese USA Flash Point 162.2±27.9 °C
Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning

 Use of Triclosan


Triclosan is an antibacterial and antifungal agent found in consumer products, including soaps, detergents, toys, and surgical cleaning treatments.

 Names

Name triclosan
Synonym More Synonyms

 Triclosan Biological Activity

Description Triclosan is an antibacterial and antifungal agent found in consumer products, including soaps, detergents, toys, and surgical cleaning treatments.
Related Catalog

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 344.6±42.0 °C at 760 mmHg
Melting Point 56-60 °C(lit.)
Molecular Formula C12H7Cl3O2
Molecular Weight 289.542
Flash Point 162.2±27.9 °C
Exact Mass 287.951172
PSA 29.46000
LogP 5.17
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.632
Storage condition Refrigerator
Stability Stable. Incompatible with strong oxidizing agents.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KO1100000
CHEMICAL NAME :
Ether, 2'-hydroxy-2,4,4'-trichlorodiphenyl
CAS REGISTRY NUMBER :
3380-34-5
LAST UPDATED :
199701
DATA ITEMS CITED :
18
MOLECULAR FORMULA :
C12-H7-Cl3-O2
MOLECULAR WEIGHT :
289.54
WISWESSER LINE NOTATION :
QR CG FOR BG DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Human
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
89 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
29 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4530 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
84 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
9300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
4400 mg/kg
SEX/DURATION :
female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TYPE OF TEST :
DNA repair
TEST SYSTEM :
Bacteria - Bacillus subtilis
DOSE/DURATION :
5 mg/disc
REFERENCE :
JOSCDQ Journal of SCCJ (Society of Cosmetic Chemists of Japan). (Nippon Keshohin Gijutsushakai, c/o Shiseido, 7-5-5 Ginza, Chuo-ku, Tokyo 104, Japan) V.10- 1976- Volume(issue)/page/year: 15,243,1981 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1355 No. of Facilities: 1242 (estimated) No. of Industries: 18 No. of Occupations: 55 No. of Employees: 73886 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1355 No. of Facilities: 4403 (estimated) No. of Industries: 33 No. of Occupations: 52 No. of Employees: 188670 (estimated) No. of Female Employees: 121892 (estimated)

 Safety Information

Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning
Hazard Statements H315-H319-H410
Precautionary Statements P273-P305 + P351 + P338-P391-P501
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi,N
Risk Phrases R36/38
Safety Phrases S26-S39-S46-S60-S61-S24/25-S22
RIDADR UN 3077 9/PG 3
WGK Germany 2
RTECS KO1100000
Packaging Group III
Hazard Class 9
HS Code 2909500000

 Synthetic Route

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Triclosan Structure

Triclosan

CAS#:3380-34-5

Literature: US6315987 B1, ;

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Triclosan Structure

Triclosan

CAS#:3380-34-5

Literature: US2011/230561 A1, ;

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Triclosan Structure

Triclosan

CAS#:3380-34-5

Literature: US2011/230561 A1, ;

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Triclosan Structure

Triclosan

CAS#:3380-34-5

Literature: EP983335 B1, ;

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Triclosan Structure

Triclosan

CAS#:3380-34-5

Literature: Antimicrobial Agents and Chemotherapy, , vol. 46, # 5 p. 1262 - 1268

 Customs

HS Code 2909500000
Summary 2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

 Articles159

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Antibacterial activity of fluoride compounds and herbal toothpastes on Streptococcus mutans: an in vitro study.

Aust. Dent. J. 60 , 368-74, (2015)

Streptococcus mutans is an important bacterial species implicated in dental caries. This laboratory study compared the antimicrobial activity of a number of fluoride containing and herbal dentifrices ...

RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine.

Antimicrob. Agents Chemother. 52 , 3604-11, (2008)

Salmonella enterica serovar Typhimurium SL1344, in which efflux pump genes (acrB, acrD, acrF, tolC) or regulatory genes thereof (marA, soxS, ramA) were inactivated, was grown in the presence of 240 an...

 Synonyms

TRICHLOSAN
IRGASAN
Irgacare MP
ch3565
Cloxifenol
ZilesanUW.
2,4,4'-trichloro-2'-hydroxydiphenyl ether
TROX-100
irgasandp300
TRICLOSAN USP
5-Chloro-2-(2,4-dichlorophenoxy)phenol
Triclosan
EINECS 222-182-2
MFCD00800992
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