123C4

Modify Date: 2026-07-01 12:51:45

123C4 Structure
123C4 structure
Common Name 123C4
CAS Number 2034159-30-1 Molecular Weight 807.34
Density N/A Boiling Point N/A
Molecular Formula C43H47ClN8O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 123C4


123C4 is a potent, selective and competitive agonist of the receptor tyrosine kinase EPHA4, with a Ki value of 0.65 μM[1].

 Names

Name 123C4

 123C4 Biological Activity

Description 123C4 is a potent, selective and competitive agonist of the receptor tyrosine kinase EPHA4, with a Ki value of 0.65 μM[1].
Related Catalog
Target

Ki: 0.65 μM (EPHA4)[1]

References

[1]. Wu B, et al. Potent and Selective EphA4 Agonists for the Treatment of ALS. Cell Chem Biol. 2017 Mar 16;24(3):293-305.

 Chemical & Physical Properties

Molecular Formula C43H47ClN8O6
Molecular Weight 807.34
InChIKey SRCCZHZOKZJHOK-IGMOWHQGSA-N
SMILES COc1ccc2[nH]cc(CCNC(=O)C(Cc3ccncc3)NC(=O)C(Cc3ccc(Cl)cc3)NC(=O)C(Cc3c[nH]c4ccc(O)cc34)NC(=O)CCCN)c2c1
Storage condition -20°C

 123C4Bioassay

View more

Name: Cytoprotective activity against patient derived induced astrocyte-mediated B6-Cg-Tg(H...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4825037
Name: Binding affinity to N-terminal His tagged EphA3 LBD (unknown origin) expressed in Ros...
Source: ChEMBL
Target: Ephrin type-A receptor 3
External Id: CHEMBL4825027
Name: Binding affinity to N-terminal His tagged EphA2 LBD (27 to 200 residues) (unknown ori...
Source: ChEMBL
Target: Ephrin type-A receptor 2
External Id: CHEMBL4825028
Name: Binding affinity to N-terminal His tagged EphA4 LBD (unknown origin) (29 to 209 resid...
Source: ChEMBL
Target: Ephrin type-A receptor 4
External Id: CHEMBL4825025
Name: Binding affinity to N-terminal His tagged EphA4 LBD (unknown origin) (29 to 209 resid...
Source: ChEMBL
Target: Ephrin type-A receptor 4
External Id: CHEMBL4825026
Name: Isothermal Titration Calorimetry (ITC) from Article 10.1016/j.chembiol.2017.01.006: "...
Source: BindingDB
Target: N/A
External Id: BindingDB_7902_2
Name: Binding affinity to N-terminal His tagged EphA4 LBD (unknown origin) (29 to 209 resid...
Source: ChEMBL
Target: Ephrin type-A receptor 4
External Id: CHEMBL4825031
Name: Aqueous solubility of compound
Source: ChEMBL
Target: N/A
External Id: CHEMBL4825029
Name: Binding affinity to N-terminal His tagged EphA4 LBD (unknown origin) (29 to 209 resid...
Source: ChEMBL
Target: Ephrin type-A receptor 4
External Id: CHEMBL4825030
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