S 3304

Modify Date: 2024-02-03 10:15:22

S 3304 Structure
S 3304 structure
 Common Name S 3304
CAS Number 203640-27-1 Molecular Weight 464.55700
Density N/A Boiling Point N/A
Molecular Formula C24H20N2O4S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of S 3304


S-3304 is a novel matrix metalloproteinases (MMP) inhibitor specific for MMP-2 and MMP-9.

 Names

Name (2R)-3-(1H-indol-3-yl)-2-[[5-[2-(4-methylphenyl)ethynyl]thiophen-2-yl]sulfonylamino]propanoic acid
Synonym More Synonyms

 S 3304 Biological Activity

Description S-3304 is a novel matrix metalloproteinases (MMP) inhibitor specific for MMP-2 and MMP-9.
Related Catalog
Target

MMP-9

In Vitro S 3304 is a novel D-tryptophan derivative and a potent, orally active, noncytotoxic Matrix metalloproteinases inhibitor (MMPI). Biochemical studies show that S 3304 most potently inhibits the activities of MMP-2 and MMP-9 but does not inhibit MMP-1, MMP-3, or MMP-7 and may, therefore, lack the musculoskeletal side effects seen with nonspecific inhibitors[1].
In Vivo In vivo pharmacologic studies have shown that the oral administration of S 3304, at a dose range of 20 to 200 mg/kg, inhibits angiogenesis, artificially induced in mice by the dorsal air-sac method. Similar oral doses of S 3304 result in potent inhibition of metastatic lung colonization of Lewis murine lung carcinoma injected via tail vein and liver metastasis of C-1H human colon cancer implanted into the spleen[1].
References

[1]. Chiappori AA, et al. A phase I pharmacokinetic and pharmacodynamic study of s-3304, a novel matrix metalloproteinase inhibitor, in patients with advanced and refractory solid tumors. Clin Cancer Res. 2007 Apr 1;13(7):2091-9.

 Chemical & Physical Properties

Molecular Formula C24H20N2O4S2
Molecular Weight 464.55700
Exact Mass 464.08600
PSA 135.88000
LogP 5.38350
Storage condition 2-8℃

 Synonyms

D-Tryptophan,N-((5-(2-(4-methylphenyl)ethynyl)-2-thienyl)sulfonyl)
UNII-BK459F050X
D-Tryptophan,N-((5-((4-methylphenyl)ethynyl)-2-thienyl)sulfonyl)
S 3304
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Chemsrc provides S 3304(CAS#:203640-27-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of S 3304 are included as well.>> amp version: S 3304

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