203640-27-1

203640-27-1 structure

Name: S 3304
Chemical Name: (2R)-3-(1H-indol-3-yl)-2-[[5-[2-(4-methylphenyl)ethynyl]thiophen-2-yl]sulfonylamino]propanoic acid
CAS Number: 203640-27-1
Molecular Formula: C₂₄H₂₀N₂O₄S₂
Molecular Weight: 464.55700
Catalog: Research Areas Cancer
Create Date: 2016-01-20 07:16:39
Modify Date: 2024-02-03 10:15:22
S-3304 is a novel matrix metalloproteinases (MMP) inhibitor specific for MMP-2 and MMP-9.

Name	(2R)-3-(1H-indol-3-yl)-2-[[5-[2-(4-methylphenyl)ethynyl]thiophen-2-yl]sulfonylamino]propanoic acid
Synonyms	D-Tryptophan,N-((5-(2-(4-methylphenyl)ethynyl)-2-thienyl)sulfonyl) UNII-BK459F050X D-Tryptophan,N-((5-((4-methylphenyl)ethynyl)-2-thienyl)sulfonyl) S 3304

Description	S-3304 is a novel matrix metalloproteinases (MMP) inhibitor specific for MMP-2 and MMP-9.
Related Catalog	Research Areas >> Cancer
Target	MMP-9
In Vitro	S 3304 is a novel D-tryptophan derivative and a potent, orally active, noncytotoxic Matrix metalloproteinases inhibitor (MMPI). Biochemical studies show that S 3304 most potently inhibits the activities of MMP-2 and MMP-9 but does not inhibit MMP-1, MMP-3, or MMP-7 and may, therefore, lack the musculoskeletal side effects seen with nonspecific inhibitors[1].
In Vivo	In vivo pharmacologic studies have shown that the oral administration of S 3304, at a dose range of 20 to 200 mg/kg, inhibits angiogenesis, artificially induced in mice by the dorsal air-sac method. Similar oral doses of S 3304 result in potent inhibition of metastatic lung colonization of Lewis murine lung carcinoma injected via tail vein and liver metastasis of C-1H human colon cancer implanted into the spleen[1].
References	[1]. Chiappori AA, et al. A phase I pharmacokinetic and pharmacodynamic study of s-3304, a novel matrix metalloproteinase inhibitor, in patients with advanced and refractory solid tumors. Clin Cancer Res. 2007 Apr 1;13(7):2091-9.