BCH
Modify Date: 2024-01-08 15:22:26
BCH structure
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Common Name | BCH | ||
|---|---|---|---|---|
| CAS Number | 20448-79-7 | Molecular Weight | 155.19400 | |
| Density | 1.256g/cm3 | Boiling Point | 295.5ºC at 760 mmHg | |
| Molecular Formula | C8H13NO2 | Melting Point | >300 °C(lit.) | |
| MSDS | USA | Flash Point | 132.5ºC | |
Use of BCHLAT1-IN-1 (BCH) is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis[1][2][3]. |
| Name | 3-aminobicyclo[2.2.1]heptane-3-carboxylic acid |
|---|---|
| Synonym | More Synonyms |
| Description | LAT1-IN-1 (BCH) is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis[1][2][3]. |
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| Related Catalog | |
| Target |
LAT1[1] |
| In Vitro | LAT1-IN-1 (1-100 mM; 3 days; KYSE30 and KYSE150 esophageal cancer cells) treatment suppresses cell proliferation in a dose-dependent manner[1]. LAT1-IN-1 (30 mM; 24 and 48 hours; KYSE30 and KYSE150 cells) treatment significantly increases cell population in the G0/G1 phase in both KYSE30 and KYSE150 cells, indicating that LAT1-IN-1 induces cell cycle arrest at G1 phase[1]. LAT1-IN-1 (30 mM; 0-24 hours; KYSE30 and KYSE150 cells) treatment decreases phosphorylation of 4E-BP1 and p70S6K at 30 minutes and the decrease is continued for 24 hours. The amount of mTOR, 4E-BP1, and p70S6K proteins is slightly decreased[1]. Cell Proliferation Assay[1] Cell Line: KYSE30 and KYSE150 esophageal cancer cells Concentration: 1 mM, 3 mM, 5 mM, 10 mM, 20 mM, 30 mM, 40 mM, 50 mM, or 100 mM Incubation Time: 3 days Result: Cell proliferation was suppressed in a dose-dependent manner. Cell Cycle Analysis[1] Cell Line: KYSE30 and KYSE150 cells Concentration: 30 mM Incubation Time: 24 and 48 hours Result: Cell cycle arrest. Western Blot Analysis[1] Cell Line: KYSE30 and KYSE150 cells Concentration: 30 mM Incubation Time: 0 hour, 0.5 hour, 1 hour, 3 hours, 6 hours, 24 hours Result: Phosphorylation of 4E-BP1 and p70S6K was decreased. The amount of mTOR, 4E-BP1, and p70S6K proteins was slightly decreased. |
| In Vivo | LAT1-IN-1 (200 mg/kg; intravenous injection; daily; for 14 days; male BALB/c nude mice) treatment significantly delays tumor growth and decreases glucose metabolism, indicating that LAT1 inhibition potentially suppresses esophageal cancer growth in vivo[1]. Animal Model: Male BALB/c nude mice (5-week-old) with KYSE150 cells[1] Dosage: 200 mg/kg Administration: Intravenous injection; daily; for 14 days Result: Significantly delayed tumor growth and decreased glucose metabolism. |
| References |
| Density | 1.256g/cm3 |
|---|---|
| Boiling Point | 295.5ºC at 760 mmHg |
| Melting Point | >300 °C(lit.) |
| Molecular Formula | C8H13NO2 |
| Molecular Weight | 155.19400 |
| Flash Point | 132.5ºC |
| Exact Mass | 155.09500 |
| PSA | 63.32000 |
| LogP | 1.28880 |
| Vapour Pressure | 0.000369mmHg at 25°C |
| Index of Refraction | 1.559 |
| RIDADR | NONH for all modes of transport |
|---|---|
| WGK Germany | 3 |
| HS Code | 2922499990 |
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~%
BCH CAS#:20448-79-7 |
| Literature: Tetrahedron Letters, , vol. 21, p. 4101 - 4104 |
![(1RS,2SR,4RS)-methyl 2-acetylamino-bicyclo[2.2.1]hept-5-ene-2-carboxylate structure](https://www.chemsrc.com/caspic/495/72431-82-4.png)
| Precursor 1 | |
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| DownStream 0 | |
| HS Code | 2922499990 |
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| Summary | HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0% |
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Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver.
Nat. Commun. 6 , 6479, (2015) Across phyla, reduced nicotinamide adenine dinucleotide phosphate (NADPH) transfers intracellular reducing power to thioredoxin reductase-1 (TrxR1) and glutathione reductase (GR), thereby supporting f... |
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Development of a cell-based screening method for compounds that inhibit or are transported by large neutral amino acid transporter 1, a key transporter at the blood-brain barrier.
Anal. Biochem. 486 , 81-5, (2015) Large neutral amino acid transporter 1 (LAT1) transports neutral amino acids with aromatic or branched side chains as well as their derivatives or prodrugs. Because the transporter is highly expressed... |
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Effects of gabapentin and pregabalin on K+-evoked 3H-GABA and 3H-glutamate release from human neocortical synaptosomes.
Naunyn Schmiedebergs Arch. Pharmacol. 379(4) , 361-9, (2009) One site of action of the anticonvulsant, analgesic, and anxiolytic drugs gabapentin and pregabalin is the alpha(2)delta-subunit of voltage-sensitive Ca(2+) channels (VSCC). We therefore analyzed the ... |
| 2-aminonorbornane-2-carboxylic acid |
| MFCD00167580 |
| b-BCH |
| 2-AMINO-2-NORBORNANE-CARBOXYLIC ACID |