P-gp inhibitor 1
Modify Date: 2024-01-10 11:26:04
P-gp inhibitor 1 structure
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Common Name | P-gp inhibitor 1 | ||
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| CAS Number | 2050747-49-2 | Molecular Weight | 517.62 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C32H31N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of P-gp inhibitor 1P-gp inhibitor 1 is a novel inhibitor reversing P-glycoprotein-mediated multidrug resistance. |
| Name | P-gp inhibitor 1 |
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| Description | P-gp inhibitor 1 is a novel inhibitor reversing P-glycoprotein-mediated multidrug resistance. |
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| Related Catalog | |
| Target |
P-glycoprotein[1] |
| In Vitro | P-gp inhibitor 1 (12k) possesses high potency (EC50=57.9±3.5 nM), low cytotoxicity, and long duration of activity in reversing doxorubicin (DOX) resistance in K562/A02 cells (1 μM, 80 minutes)[1]. P-gp inhibitor 1 also boosts the potency of other MDR-related cytotoxic agents with different structures, increases accumulation of DOX, blocks Pgp-mediated Rh123 efflux, and suppresses P-gp ATPase activity in K562/A02 MDR cells (0.1, 1, 5 μM, 1 hour)[1]. Western Blot Analysis[1] Cell Line: K562/A02 cell Concentration: 0.1, 0.5, or 2.0 μM Incubation Time: 72 hours Result: MDR reversal by 12k was not caused by a decreased protein expression but instead most likely due to direct inhibition of P-gp efflux[1]. |
| References |
| Molecular Formula | C32H31N5O2 |
|---|---|
| Molecular Weight | 517.62 |