BTM-3528

Modify Date: 2024-01-12 17:22:07

BTM-3528 structure	Common Name	BTM-3528
	CAS Number	2054998-45-5	Molecular Weight	521.55
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₁₉F₄N₃O₂S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of BTM-3528

BTM-3528 is an activator of the mitochondrial protease OMA1 and mediates excessive activation of the mitochondrial integrated stress response (ISR). BTM-3528 stimulates OMA1-dependent DELE1 and OPA1 cleavage and mitochondrial fragmentation. BTM-3528 activates eIF2α kinase HRI, inducing cell growth arrest and apoptosis. BTM-3528 has anticancer activity against multiple DLBCL cell lines and has in vivo inhibitory potency in a mouse model xenografted with human DLBCL SU-DHL-10 cells[1].

Name	BTM-3528

Description	BTM-3528 is an activator of the mitochondrial protease OMA1 and mediates excessive activation of the mitochondrial integrated stress response (ISR). BTM-3528 stimulates OMA1-dependent DELE1 and OPA1 cleavage and mitochondrial fragmentation. BTM-3528 activates eIF2α kinase HRI, inducing cell growth arrest and apoptosis. BTM-3528 has anticancer activity against multiple DLBCL cell lines and has in vivo inhibitory potency in a mouse model xenografted with human DLBCL SU-DHL-10 cells[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Eukaryotic Initiation Factor (eIF)
References	[1]. Schwarzer A, et al. Targeting aggressive B-cell lymphomas through pharmacological activation of the mitochondrial protease OMA1. Mol Cancer Ther. 2023 Aug 30.. .

Molecular Formula	C₂₄H₁₉F₄N₃O₂S₂
Molecular Weight	521.55

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: BTM-3528
Price: Click To Check
Purity: 99.37%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Get all suppliers and price by the below link:

BTM-3528 suppliers

BTM-3528 price

BTM-3528

Use of BTM-3528

Names

BTM-3528 Biological Activity

Chemical & Physical Properties