BRD3731
Modify Date: 2024-04-02 04:54:30
BRD3731 structure
|
Common Name | BRD3731 | ||
|---|---|---|---|---|
| CAS Number | 2056262-08-7 | Molecular Weight | 377.532 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H31N3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BRD3731BRD3731 is a potent, selective GSK3β inhibitor with IC50 of 15 nM, 14-fold selectivity for GSK3β over GSK3α (IC50=215 nM); displays excellent selectivity in a penal of 311 kinases, displays reduced potency toward the GSK3β mutant (D133E) with IC50 of 53 nM; induces β-catenin stabilization starting at 20 uM in the HL-60 AML cell line, decreases β-catenin S33/37/T41 phosphorylation and induces β-catenin S675 phosphorylation, resulting in increased β-catenin. |
| Name | BRD3731 |
|---|
| Description | BRD3731 is a potent, selective GSK3β inhibitor with IC50 of 15 nM, 14-fold selectivity for GSK3β over GSK3α (IC50=215 nM); displays excellent selectivity in a penal of 311 kinases, displays reduced potency toward the GSK3β mutant (D133E) with IC50 of 53 nM; induces β-catenin stabilization starting at 20 uM in the HL-60 AML cell line, decreases β-catenin S33/37/T41 phosphorylation and induces β-catenin S675 phosphorylation, resulting in increased β-catenin. |
|---|---|
| References | References 1. Wagner FF, et al. Sci Transl Med. 2018 Mar 7;10(431). pii: eaam8460. View Related Products by Target GSK-3 |
| Molecular Formula | C24H31N3O |
|---|---|
| Molecular Weight | 377.532 |