2056262-08-7
2056262-08-7 structure
- Name: BRD3731
- Chemical Name: BRD3731
- CAS Number: 2056262-08-7
- Molecular Formula: C24H31N3O
- Molecular Weight: 377.532
- Catalog: Signaling Pathways PI3K/Akt/mTOR GSK-3
- Create Date: 2020-01-20 18:40:56
- Modify Date: 2026-07-18 22:20:35
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BRD3731 is a potent, selective GSK3β inhibitor with IC50 of 15 nM, 14-fold selectivity for GSK3β over GSK3α (IC50=215 nM); displays excellent selectivity in a penal of 311 kinases, displays reduced potency toward the GSK3β mutant (D133E) with IC50 of 53 nM; induces β-catenin stabilization starting at 20 uM in the HL-60 AML cell line, decreases β-catenin S33/37/T41 phosphorylation and induces β-catenin S675 phosphorylation, resulting in increased β-catenin.
| Name | BRD3731 |
|---|---|
| Synonyms |
(4R)-3-(2,2-dimethylpropyl)-4,7,7-trimethyl-4-phenyl-2,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one
(R)-BRD3731 5H-Pyrazolo[3,4-b]quinolin-5-one, 3-(2,2-dimethylpropyl)-1,2,4,6,7,8-hexahydro-4,7,7-trimethyl-4-phenyl-, (4R) BRD3731 (BRD-3731 |
| Description | BRD3731 is a potent, selective GSK3β inhibitor with IC50 of 15 nM, 14-fold selectivity for GSK3β over GSK3α (IC50=215 nM); displays excellent selectivity in a penal of 311 kinases, displays reduced potency toward the GSK3β mutant (D133E) with IC50 of 53 nM; induces β-catenin stabilization starting at 20 uM in the HL-60 AML cell line, decreases β-catenin S33/37/T41 phosphorylation and induces β-catenin S675 phosphorylation, resulting in increased β-catenin. |
|---|---|
| References | References 1. Wagner FF, et al. Sci Transl Med. 2018 Mar 7;10(431). pii: eaam8460. View Related Products by Target GSK-3 |
| Molecular Formula | C24H31N3O |
|---|---|
| Molecular Weight | 377.532 |