(Z)-Lafutidine
Modify Date: 2024-01-10 17:45:50
(Z)-Lafutidine structure
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Common Name | (Z)-Lafutidine | ||
|---|---|---|---|---|
| CAS Number | 206449-93-6 | Molecular Weight | 431.54800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H29N3O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (Z)-Lafutidine(Z)-Lafutidine ((Z)-FRG-8813) is a potent histamine H2 receptor antagonist. (Z)-Lafutidine shows anti-secretory and gastroprotective activities[1]. |
| Name | 2-(furan-2-ylmethylsulfinyl)-N-[4-[4-(piperidin-1-ylmethyl)pyridin-2-yl]oxybut-2-enyl]acetamide |
|---|---|
| Synonym | More Synonyms |
| Description | (Z)-Lafutidine ((Z)-FRG-8813) is a potent histamine H2 receptor antagonist. (Z)-Lafutidine shows anti-secretory and gastroprotective activities[1]. |
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| Related Catalog | |
| In Vivo | (Z)-Lafutidine (Compound 16) stimulates mucin biosynthesis in rat gastric mucosa and this effect not directly due to histamine H2 receptor antagonism[1]. Animal Model: Eight- to nine-week-old male C57BL/6 mice weighing 20-24g[1] Dosage: 3-30 mg/kg Administration: P.o; twice for 6 days (5-FU: 50 mg/kg; i.p.;once daily) Result: Reduced the severity of diarrhea during 5-FU treatment,in a mostly dose-dependent manner, and a significant effect was observed at a dose of 30 mg/kg. |
| References |
| Molecular Formula | C22H29N3O4S |
|---|---|
| Molecular Weight | 431.54800 |
| Exact Mass | 431.18800 |
| PSA | 107.37000 |
| LogP | 4.30450 |
| rac Lafutidine |