2,3-Dihydrofisetin
Modify Date: 2025-09-01 19:45:30
2,3-Dihydrofisetin structure
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Common Name | 2,3-Dihydrofisetin | ||
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| CAS Number | 20725-03-5 | Molecular Weight | 288.252 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 644.2±55.0 °C at 760 mmHg | |
| Molecular Formula | C15H12O6 | Melting Point | 216-217ºC | |
| MSDS | N/A | Flash Point | 249.2±25.0 °C | |
Use of 2,3-DihydrofisetinFustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) is a potent amyloid β (Aβ) inhibitor. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases the expression of acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) decreases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) can be used for Alzheimer's disease research[1]. |
| Name | fustin |
|---|---|
| Synonym | More Synonyms |
| Description | Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) is a potent amyloid β (Aβ) inhibitor. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases the expression of acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) decreases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) can be used for Alzheimer's disease research[1]. |
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| Related Catalog | |
| In Vivo | Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) attenuates Aβ (1-42)-induced impairments in conditioned fear learning and passive avoidance behavior[1]. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) alters Aβ (1-42)-induced changes in ACh level and AChE and ChAT activity and gene expression[1]. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) increases Aβ (1-42)-induced reduction in M1 receptor mRNA and protein expression in Aβ-treated C57BL/6 mice. Fustin increases p-ERK and p-CREB expression in Aβ-treated C57BL/6 mice[1]. Animal Model: Aβ-treated C57BL/6 mice[1] Dosage: 50 and 100 mg/kg Administration: Oral administration;daily, for 11days Result: Decreased freezing response in Aβ-treated C57BL/6 mice. Animal Model: Aβ-treated C57BL/6 mice[1] Dosage: 50 and 100 mg/kg Administration: Oral administration;daily, for 11days Result: Increased the expression of Ach, ChAT gene and ChAT activity. Decreased the expression of AChE gene and AChE activity. Animal Model: Aβ-treated C57BL/6 mice[1] Dosage: 50 and 100 mg/kg Administration: Oral administration;daily, for 11days Result: Increased gene expression of M2- , M3- ,M4-, M5-, α4β, α7-receptor, p-ERK and p-CREB. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 644.2±55.0 °C at 760 mmHg |
| Melting Point | 216-217ºC |
| Molecular Formula | C15H12O6 |
| Molecular Weight | 288.252 |
| Flash Point | 249.2±25.0 °C |
| Exact Mass | 288.063385 |
| PSA | 107.22000 |
| LogP | 1.38 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.729 |
| 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-2,3-dihydro-4H-chromen-4-one |
| 3,7,3',4'-tetrahydroxyflavone |
| 5-Deoxydihydrouercetin |
| 3',4',7-TRIHYDROXYFLAVANONOL |
| 3,3',4',7-tetrahydroxyflavanone |
| 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy- |
| DIHYDROFISETIN |
| 2,3-Dihydrofisetin |
| 2,3-DIHYDROFISETH |
| FUSTIN |
| 3,7,3',4'-tetrahydroxyflavanone |