Saikosaponin C

Modify Date: 2024-01-02 13:18:38

Saikosaponin C Structure
Saikosaponin C structure
Common Name Saikosaponin C
CAS Number 20736-08-7 Molecular Weight 943.122
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C48H78O18 Melting Point 310-314ºC
MSDS Chinese USA Flash Point N/A

 Use of Saikosaponin C


Saikosaponin C is a bioactive component found in radix bupleuri, targets amyloid beta and tau in Alzheimer's disease. Saikosaponin C inhibits the secretion of both Aβ1-40 and Aβ1-42, and suppresses abnormal tau phosphorylation, but shows no effect on BACE1 activity and expression[1].

 Names

Name Saikosaponin C
Synonym More Synonyms

 Saikosaponin C Biological Activity

Description Saikosaponin C is a bioactive component found in radix bupleuri, targets amyloid beta and tau in Alzheimer's disease. Saikosaponin C inhibits the secretion of both Aβ1-40 and Aβ1-42, and suppresses abnormal tau phosphorylation, but shows no effect on BACE1 activity and expression[1].
Related Catalog
References

[1]. Lee TH1, et al. A potential therapeutic effect of saikosaponin C as a novel dual-target anti-Alzheimer agent. J Neurochem. 2016 Mar;136(6):1232-1245.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Melting Point 310-314ºC
Molecular Formula C48H78O18
Molecular Weight 943.122
Exact Mass 942.518799
PSA 287.14000
LogP 2.35
Index of Refraction 1.632

 Safety Information

Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases S26

 Synonyms

Saikosaponin c standard
(3β,16β)-16,23-dihydroxy-13,28-epoxyolean-11-en-3-yl 6-deoxy-α-L-altropyranosyl-(1->4)-[β-D-glucopyranosyl-(1->6)]-β-D-glucopyranoside
SaikosaponinC
β-D-glucopyranoside, (3β,16β)-13,28-epoxy-16,23-dihydroxyolean-11-en-3-yl O-6-deoxy-α-L-altropyranosyl-(1->4)-O-[β-D-glucopyranosyl-(1->6)]-
Saikosaponin C
SAIKOSAPONIN A(P)
Saikosaponian C
β-D-Glucopyranoside, (3β,16β)-13,28-epoxy-16,23-dihydroxyolean-11-en-3-yl O-6-deoxy-β-L-altropyranosyl-(1->4)-O-[β-D-glucopyranosyl-(1->6)]-
chikusakoside II
SAIKOSAPONIN C(P)
(3β,16β)-16,23-Dihydroxy-13,28-epoxyolean-11-en-3-yl 6-deoxy-β-L-altropyranosyl-(1->4)-[β-D-glucopyranosyl-(1->6)]-β-D-glucopyranoside
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