Trifluridine-13C,15N2

Modify Date: 2024-01-14 11:03:13

Trifluridine-13C,15N2 Structure
Trifluridine-13C,15N2 structure
Common Name Trifluridine-13C,15N2
CAS Number 2086328-10-9 Molecular Weight 299.18
Density N/A Boiling Point N/A
Molecular Formula C913CH11F315N2O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Trifluridine-13C,15N2


Trifluridine-13C,15N2 is the 13C and 15N labeled Trifluridine[1]. Trifluridine (Trifluorothymidine;5-Trifluorothymidine;TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral drug for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity[2].

 Names

Name Trifluridine-13C,15N2

 Trifluridine-13C,15N2 Biological Activity

Description Trifluridine-13C,15N2 is the 13C and 15N labeled Trifluridine[1]. Trifluridine (Trifluorothymidine;5-Trifluorothymidine;TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral drug for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52.  

 Chemical & Physical Properties

Molecular Formula C913CH11F315N2O5
Molecular Weight 299.18