Tz-Thalidomide

Modify Date: 2025-10-05 19:17:44

Tz-Thalidomide structure	Common Name	Tz-Thalidomide
	CAS Number	2087490-42-2	Molecular Weight	571.58
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₉H₂₉N₇O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Tz-Thalidomide

Tz-Thalidomide is a tetrazine tagged Thalidomide (HY-14658) (Ligands for E3 Ligase). Tz-Thalidomide has binding affinity for BRD4, with IC50s of 46.25 μM (BRD4-1) and 62.55 μM (BRD4-2)[1].

Name	6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-N-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzyl)hexanamide

Description	Tz-Thalidomide is a tetrazine tagged Thalidomide (HY-14658) (Ligands for E3 Ligase). Tz-Thalidomide has binding affinity for BRD4, with IC50s of 46.25 μM (BRD4-1) and 62.55 μM (BRD4-2)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	46.25 μM (BRD4-1), 62.55 μM (BRD4-2)[1]
References	[1]. Lebraud H, et al. Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras. ACS Cent Sci. 2016 Dec 28;2(12):927-934.

Molecular Formula	C₂₉H₂₉N₇O₆
Molecular Weight	571.58

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Tz-Thalidomide

Use of Tz-Thalidomide

Names

Tz-Thalidomide Biological Activity

Chemical & Physical Properties

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