FLT3-IN-5e

Modify Date: 2024-02-23 17:18:18

FLT3-IN-5e Structure
FLT3-IN-5e structure
Common Name FLT3-IN-5e
CAS Number 2093038-25-4 Molecular Weight 305.385
Density N/A Boiling Point N/A
Molecular Formula C18H19N5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of FLT3-IN-5e


FLT3-IN-5e is a nove potent, selective FLT3 inhibitor with Kd of 3.6 nM, IC50 of <6 nM; has high potentcy against mutant FLT3 D835H, D835V, D835Y, ITD-D835V, ITD-F691L, K663Q, N841I, and R834Q (Kd=0.36-82 nM); shows weak (8-fold selectivity) activity for PDGFRB (28 nM) and the JAK1 JH2 domain (28 nM); possesses growth inhibitory potencies against MOLM13 FLT3-ITD and MOLM13 FLT3-ITD/D835Y cells.

 Names

Name FLT3-IN-5e

 FLT3-IN-5e Biological Activity

Description FLT3-IN-5e is a nove potent, selective FLT3 inhibitor with Kd of 3.6 nM, IC50 of <6 nM; has high potentcy against mutant FLT3 D835H, D835V, D835Y, ITD-D835V, ITD-F691L, K663Q, N841I, and R834Q (Kd=0.36-82 nM); shows weak (8-fold selectivity) activity for PDGFRB (28 nM) and the JAK1 JH2 domain (28 nM); possesses growth inhibitory potencies against MOLM13 FLT3-ITD and MOLM13 FLT3-ITD/D835Y cells.
References References 1. Jarusiewicz JA, et al. ACS Omega. 2017 May 31;2(5):1985-2009. View Related Products by Target FLT3

 Chemical & Physical Properties

Molecular Formula C18H19N5
Molecular Weight 305.385
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