rel-Zotatifin

Modify Date: 2024-04-05 01:06:01

rel-Zotatifin Structure
rel-Zotatifin structure
Common Name rel-Zotatifin
CAS Number 2098191-54-7 Molecular Weight 487.55
Density N/A Boiling Point N/A
Molecular Formula C28H29N3O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of rel-Zotatifin


rel-Zotatifin is the racemic isomer of Zotatifin, acts as an eIF4A inhibitor with activity less than Zotatifin. Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC50=2 nM) and interferes with the assembly of the eIF4F initiation complex.

 Names

Name rel-Zotatifin

 rel-Zotatifin Biological Activity

Description rel-Zotatifin is the racemic isomer of Zotatifin, acts as an eIF4A inhibitor with activity less than Zotatifin. Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC50=2 nM) and interferes with the assembly of the eIF4F initiation complex.

 Chemical & Physical Properties

Molecular Formula C28H29N3O5
Molecular Weight 487.55
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