Mal-amido-PEG12-NHS

Modify Date: 2024-01-11 23:33:53

Mal-amido-PEG12-NHS Structure
Mal-amido-PEG12-NHS structure
Common Name Mal-amido-PEG12-NHS
CAS Number 2101722-60-3 Molecular Weight 865.92
Density N/A Boiling Point N/A
Molecular Formula C38H63N3O19 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Mal-amido-PEG12-NHS


Mal-amido-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Mal-amido-PEG12-NHS ester
Synonym More Synonyms

 Mal-amido-PEG12-NHS Biological Activity

Description Mal-amido-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C38H63N3O19
Molecular Weight 865.92

 Synonyms

MFCD11041148