MDTF free acid

Modify Date: 2024-04-03 11:35:59

MDTF free acid structure	Common Name	MDTF free acid
	CAS Number	2102021-49-6	Molecular Weight	469.32
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₁F₄NO₉S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MDTF free acid

MDTF free acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Name	MDTF free acid

Description	MDTF free acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
In Vitro	MDTF free acid (50 μM) increases hydrophilic character by substitution of a cyclohexyl ring and a MD-based FRET probe incubates in human plasma has a considerably higher self-stabilization rate compared to the MCC-based probe[1].
References	[1]. Dovgan I, et, al. 2-(Maleimidomethyl)-1,3-Dioxanes (MD): a Serum-Stable Self-hydrolysable Hydrophilic Alternative to Classical Maleimide Conjugation. Sci Rep. 2016 Aug 9;6:30835.

Molecular Formula	C₁₆H₁₁F₄NO₉S
Molecular Weight	469.32