2-amino-9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-methylsulfanyl-3H-purin-6-one

Modify Date: 2024-02-02 01:10:20

2-amino-9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-methylsulfanyl-3H-purin-6-one Structure
2-amino-9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-methylsulfanyl-3H-purin-6-one structure
Common Name 2-amino-9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-methylsulfanyl-3H-purin-6-one
CAS Number 2104-66-7 Molecular Weight 329.33
Density 2.12g/cm3 Boiling Point 757.3ºC at 760 mmHg
Molecular Formula C11H15N5O5S Melting Point N/A
MSDS N/A Flash Point 411.8ºC

 Use of 2-amino-9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-methylsulfanyl-3H-purin-6-one


8-(Methylthio)guanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

 Names

Name 4-(4-chloroanilino)-4-oxobutanoic acid
Synonym More Synonyms

  Biological Activity

Description 8-(Methylthio)guanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].
Related Catalog
References

[1]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.  

 Chemical & Physical Properties

Density 2.12g/cm3
Boiling Point 757.3ºC at 760 mmHg
Molecular Formula C11H15N5O5S
Molecular Weight 329.33
Flash Point 411.8ºC
Exact Mass 329.07900
PSA 184.81000
Vapour Pressure 4.18E-24mmHg at 25°C
Index of Refraction 1.915

 Synonyms

8-methylsulfanyl-guanosine
8-Methylmercapto-guanosin
8-Methylthioguanosin
8-methylthioguanosine
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