3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-onedihydrochloride

Modify Date: 2024-01-08 20:03:04

3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-onedihydrochloride Structure
3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-onedihydrochloride structure
Common Name 3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-onedihydrochloride
CAS Number 210688-56-5 Molecular Weight 422.39100
Density N/A Boiling Point N/A
Molecular Formula C22H29Cl2N3O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-onedihydrochloride


PD 168568 is a orally active and potent dopamine receptor D4 (DRD4) antagonist. PD 168568 contains an isoindolinone and is selective for the D4 receptor versus D2 and D3, with Ki values of 8.8, 1842, and 2682 nM, respectively. PD 168568 can be used for glioblastoma (GBM) research[1][2].

 Names

Name 3-[2-[4-(3,4-dimethylphenyl)piperazin-1-yl]ethyl]-2,3-dihydroisoindol-1-one,dihydrochloride

  Biological Activity

Description PD 168568 is a orally active and potent dopamine receptor D4 (DRD4) antagonist. PD 168568 contains an isoindolinone and is selective for the D4 receptor versus D2 and D3, with Ki values of 8.8, 1842, and 2682 nM, respectively. PD 168568 can be used for glioblastoma (GBM) research[1][2].
Related Catalog
Target

D4 Receptor:8.8 nM (Ki)

D2 Receptor:1842 nM (Ki)

D3 Receptor:2682 nM (Ki)

In Vitro PD 168568 对胶质母细胞瘤神经干细胞 (GNS) 表现出选择性抑制,IC50 为 25-50 µM[1]。
In Vivo PD 168568 (3 mg/kg,口服) 可抑制大鼠 amphetamine 刺激的运动活动[3]。 Animal Model: Rat[1] Dosage: 3 mg/kg Administration: Oral administration Result: Inhibited amphetamine (0.5 mg/kg, i.p.) stimulated locomotor activity.
References

[1]. Dolma S, et al. Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell. 2016 Jun 13;29(6):859-873.  

[2]. Lindsley CW, et al. Return of D4 Dopamine Receptor Antagonists in Drug Discovery. J Med Chem. 2017 Sep 14;60(17):7233-7243.  

[3]. Belliotti TR, et al. Isoindolinone enantiomers having affinity for the dopamine D4 receptor. Bioorg Med Chem Lett. 1998 Jun 16;8(12):1499-502.  

 Chemical & Physical Properties

Molecular Formula C22H29Cl2N3O
Molecular Weight 422.39100
Exact Mass 421.16900
PSA 35.58000
LogP 5.23590

 Synthetic Route

~58%

3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-onedihydrochloride Structure

3-[2-[4-(3,4-di...

CAS#:210688-56-5

Literature: Warner-Lambert Company Patent: US6087364 A1, 2000 ; US 6087364 A

~%

3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-onedihydrochloride Structure

3-[2-[4-(3,4-di...

CAS#:210688-56-5

Literature: Belliotti, Thomas R.; Brink, Wouter A.; Kesten, Suzanne R.; Rubin, John R.; Wustrow, David J.; Zoski, Kim T.; Whetzel, Steven Z.; Corbin, Ann E.; Pugsley, Thomas A.; Heffner, Thomas G.; Wise, Lawrence D. Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 12 p. 1499 - 1502

~%

3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-onedihydrochloride Structure

3-[2-[4-(3,4-di...

CAS#:210688-56-5

Literature: Warner-Lambert Company Patent: US6087364 A1, 2000 ; US 6087364 A

~%

3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-onedihydrochloride Structure

3-[2-[4-(3,4-di...

CAS#:210688-56-5

Literature: Warner-Lambert Company Patent: US6087364 A1, 2000 ; US 6087364 A

~%

3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-onedihydrochloride Structure

3-[2-[4-(3,4-di...

CAS#:210688-56-5

Literature: Warner-Lambert Company Patent: US6087364 A1, 2000 ; US 6087364 A

~%

3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-onedihydrochloride Structure

3-[2-[4-(3,4-di...

CAS#:210688-56-5

Literature: Belliotti, Thomas R.; Brink, Wouter A.; Kesten, Suzanne R.; Rubin, John R.; Wustrow, David J.; Zoski, Kim T.; Whetzel, Steven Z.; Corbin, Ann E.; Pugsley, Thomas A.; Heffner, Thomas G.; Wise, Lawrence D. Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 12 p. 1499 - 1502
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