W-84 dibromide structure
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Common Name | W-84 dibromide | ||
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CAS Number | 21093-51-6 | Molecular Weight | 708.52400 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C32H44Br2N4O4 | Melting Point | N/A | |
MSDS | Chinese USA | Flash Point | N/A | |
Symbol |
GHS07 |
Signal Word | Warning |
Use of W-84 dibromideW-84 (dibromide) is a potent allosteric modulator of M2-cholinoceptors, which retards [3H]N-methylscopolamine dissociation. W-84 dibromide can stabilize cholinergic antagonist-receptor complexes. W-84 (dibromide) is a non-competitive muscarinic acetylcholine receptors antagonist with allosteric effects. W-84 (dibromide) protects over additively against an organophosphate-intoxication when applied in combination with atropine[1][2][3]. |
Name | 3-(1,3-dioxoisoindol-2-yl)propyl-[6-[3-(1,3-dioxoisoindol-2-yl)propyl-dimethylazaniumyl]hexyl]-dimethylazanium,dibromide |
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Synonym | More Synonyms |
Description | W-84 (dibromide) is a potent allosteric modulator of M2-cholinoceptors, which retards [3H]N-methylscopolamine dissociation. W-84 dibromide can stabilize cholinergic antagonist-receptor complexes. W-84 (dibromide) is a non-competitive muscarinic acetylcholine receptors antagonist with allosteric effects. W-84 (dibromide) protects over additively against an organophosphate-intoxication when applied in combination with atropine[1][2][3]. |
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Related Catalog | |
Target |
muscarinic acetylcholine receptors[1] |
In Vitro | The stabilizing effect of W-84 (dibromide) on antagonist-receptor complexes may explain the overadditive protective action exerted by the combination of atropine and W-84 (dibromide) against organophosphate intoxication[1]. W-84 (dibromide) not only inhibits radioligand association but also strongly stabilizes antagonist-receptor complexes[2]. |
References |
Molecular Formula | C32H44Br2N4O4 |
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Molecular Weight | 708.52400 |
Exact Mass | 706.17300 |
PSA | 74.76000 |
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H315-H319-H335 |
Precautionary Statements | P261-P305 + P351 + P338 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xi |
RIDADR | NONH for all modes of transport |
~96% W-84 dibromide CAS#:21093-51-6 |
Literature: Heller, Eberhard; Lautenschlaeger, Werner; Holzgrabe, Ulrike Tetrahedron Letters, 2009 , vol. 50, # 12 p. 1321 - 1323 |
~% W-84 dibromide CAS#:21093-51-6 |
Literature: Schmitz, Jens; Heller, Eberhard; Holzgrabe, Ulrike Monatshefte fur Chemie, 2007 , vol. 138, # 2 p. 171 - 174 |
~% W-84 dibromide CAS#:21093-51-6 |
Literature: Schmitz, Jens; Heller, Eberhard; Holzgrabe, Ulrike Monatshefte fur Chemie, 2007 , vol. 138, # 2 p. 171 - 174 |
Potentiation by alcuronium of the antimuscarinic effect of N-methylscopolamine in guinea pig left atria.
Eur. J. Pharmacol. 272 , 103-106, (1995) Alcuronium is known to stabilize allosterically the binding of the muscarinic antagonist N-methylscopolamine to muscarinic M2 receptors and thus to elevate the equilibrium binding of N-methylscopolami... |
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Allosteric modulation of G protein-coupled receptors: perspectives and recent developments.
Drug Discov. Today 9 , 752-758, (2004) Allosteric modulation of G protein-coupled receptors has recently been recognized as an alternative approach to gain selectivity in drug action. In this overview, allosteric modulators that enhance or... |
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A stable and highly potent hexamethonium derivative which modulates muscarinic receptors allosterically in guinea-pig hearts.
J. Pharm. Pharmacol. 46(2) , 108-12, (1994) W84 (N,N,N',N'-tetramethyl-N,N'-bis-(3-phthalimidopropyl)-N,N'-hexane- 1,6- diyl-bis-ammonium dibromide) is a potent stabilizer of antagonist binding to muscarinic receptors; however, W84 hydrolyses i... |
Hexamethylene-bis-[dimethyl-(3-phthalimidopropyl)ammonium]dibromide |
Hdmppa |
W-84 dibromide |
W-84 |