MU 380
Modify Date: 2024-01-06 10:02:03
MU 380 structure
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Common Name | MU 380 | ||
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| CAS Number | 2109805-78-7 | Molecular Weight | 430.226 | |
| Density | 1.9±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C15H15BrF3N7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MU 380A novel potent, selective CHK1 inhibitor 2 nM, >80-fold selectivity over CHK2; sensitizes a variety of tumor cell lines to hydroxyurea or gemcitabine up to 10 times; shows extended inhibitory effects in cells, and unlike SCH900776, does not undergo in vivo N-dealkylation to the significantly less selective metabolite; causes higher accumulation of DNA damage in tumor cells and subsequent enhanced cell death, and is more efficacious in the A2780 xenograft mouse model. |
| Name | 6-Bromo-5-[(3R)-3-piperidinyl]-3-[1-(trifluoromethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidin-7-amine |
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| Synonym | More Synonyms |
| Description | A novel potent, selective CHK1 inhibitor 2 nM, >80-fold selectivity over CHK2; sensitizes a variety of tumor cell lines to hydroxyurea or gemcitabine up to 10 times; shows extended inhibitory effects in cells, and unlike SCH900776, does not undergo in vivo N-dealkylation to the significantly less selective metabolite; causes higher accumulation of DNA damage in tumor cells and subsequent enhanced cell death, and is more efficacious in the A2780 xenograft mouse model. |
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| References | References 1. Samadder P, et al. Mol Cancer Ther. 2017 Sep;16(9):1831-1842. View Related Products by Target Checkpoint Kinase (Chk) |
| Density | 1.9±0.1 g/cm3 |
|---|---|
| Molecular Formula | C15H15BrF3N7 |
| Molecular Weight | 430.226 |
| Exact Mass | 429.052429 |
| LogP | 1.78 |
| Index of Refraction | 1.750 |
| Pyrazolo[1,5-a]pyrimidin-7-amine, 6-bromo-5-[(3R)-3-piperidinyl]-3-[1-(trifluoromethyl)-1H-pyrazol-4-yl]- |
| 6-Bromo-5-[(3R)-3-piperidinyl]-3-[1-(trifluoromethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidin-7-amine |