PHI-101

Modify Date: 2024-01-21 11:37:27

PHI-101 Structure
PHI-101 structure
 Common Name PHI-101
CAS Number 2127107-15-5 Molecular Weight 386.44
Density N/A Boiling Point N/A
Molecular Formula C19H19FN4O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PHI-101


PHI-101 is an orally active FLT3 inhibitor that overcomes resistance to multiple drug-resistant mutations. PHI-101 potently inhibits FLT3 single activating mutations (ITD or TKD mutants) and has inhibitory activity against FLT3 double (ITD/D835Y or ITD/F691L) and triple (ITD/D835Y/F691L) resistance mutations. PHI-101 has potential for research in relapsed or refractory acute myeloid leukemia (AML)[1].

 Names

Name PHI-101

 PHI-101 Biological Activity

Description PHI-101 is an orally active FLT3 inhibitor that overcomes resistance to multiple drug-resistant mutations. PHI-101 potently inhibits FLT3 single activating mutations (ITD or TKD mutants) and has inhibitory activity against FLT3 double (ITD/D835Y or ITD/F691L) and triple (ITD/D835Y/F691L) resistance mutations. PHI-101 has potential for research in relapsed or refractory acute myeloid leukemia (AML)[1].
Related Catalog
References

[1]. Nam K Y, et al. PHI-101 Is a Potent Third-Generation FLT3 Inhibitor Developed to Overcome Resistance in Acute Myeloid Leukemia[J]. Blood, 2020, 136: 28.

 Chemical & Physical Properties

Molecular Formula C19H19FN4O2S
Molecular Weight 386.44
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Chemsrc provides PHI-101(CAS#:2127107-15-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of PHI-101 are included as well.>> amp version: PHI-101

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