YW1128
Modify Date: 2024-01-04 19:43:11
YW1128 structure
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Common Name | YW1128 | ||
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| CAS Number | 2131223-64-6 | Molecular Weight | 343.382 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C20H17N5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of YW1128YW1128 is an inhibitor of Wnt/��-catenin signaling with an IC50 value of 4.1 nM in a reporter assay. |
| Name | 5-Methyl-1-(2-methylphenyl)-N-(2-quinolinyl)-1H-1,2,3-triazole-4-carboxamide |
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| Synonym | More Synonyms |
| Description | YW1128 is an inhibitor of Wnt/��-catenin signaling with an IC50 value of 4.1 nM in a reporter assay. |
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| In Vitro | YW1128 is an inhibitor of Wnt/��-catenin signaling with an IC50 value of 4.1 nM in a reporter assay.It decreases protein levels of ��-catenin in the presence of the GSK3�� inhibitor lithium chloride and increases protein levels of Axin1 in HEK293 cells. YW1128 decreases lipid accumulation and the expression of gluconeogenic and lipogenic genes in Huh7 cells. It decreases the hepatic expression of Wnt target genes, improves glucose tolerance, and prevents body weight increases and hepatic lipid accumulation in mice fed a high-fat diet, but not mice fed normal chow, when administered at a dose of 40 mg/kg every other day for 11 weeks. |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C20H17N5O |
| Molecular Weight | 343.382 |
| Exact Mass | 343.143311 |
| LogP | 3.13 |
| Index of Refraction | 1.687 |
| 5-Methyl-1-(2-methylphenyl)-N-(2-quinolinyl)-1H-1,2,3-triazole-4-carboxamide |
| 1H-1,2,3-Triazole-4-carboxamide, 5-methyl-1-(2-methylphenyl)-N-2-quinolinyl- |