2131223-64-6

2131223-64-6 structure

Name: YW1128
Chemical Name: 5-Methyl-1-(2-methylphenyl)-N-(2-quinolinyl)-1H-1,2,3-triazole-4-carboxamide
CAS Number: 2131223-64-6
Molecular Formula: C₂₀H₁₇N₅O
Molecular Weight: 343.382
Catalog: Signaling Pathways Stem Cell/Wnt Wnt
Create Date: 2020-01-12 09:16:34
Modify Date: 2024-01-04 19:43:11
YW1128 is an inhibitor of Wnt/��-catenin signaling with an IC50 value of 4.1 nM in a reporter assay.

Name	5-Methyl-1-(2-methylphenyl)-N-(2-quinolinyl)-1H-1,2,3-triazole-4-carboxamide
Synonyms	5-Methyl-1-(2-methylphenyl)-N-(2-quinolinyl)-1H-1,2,3-triazole-4-carboxamide 1H-1,2,3-Triazole-4-carboxamide, 5-methyl-1-(2-methylphenyl)-N-2-quinolinyl-

Description	YW1128 is an inhibitor of Wnt/��-catenin signaling with an IC50 value of 4.1 nM in a reporter assay.
In Vitro	YW1128 is an inhibitor of Wnt/��-catenin signaling with an IC50 value of 4.1 nM in a reporter assay.It decreases protein levels of ��-catenin in the presence of the GSK3�� inhibitor lithium chloride and increases protein levels of Axin1 in HEK293 cells. YW1128 decreases lipid accumulation and the expression of gluconeogenic and lipogenic genes in Huh7 cells. It decreases the hepatic expression of Wnt target genes, improves glucose tolerance, and prevents body weight increases and hepatic lipid accumulation in mice fed a high-fat diet, but not mice fed normal chow, when administered at a dose of 40 mg/kg every other day for 11 weeks.