BETd-260 trifluoroacetate

Modify Date: 2024-05-10 13:40:51

BETd-260 trifluoroacetate Structure
BETd-260 trifluoroacetate structure
 Common Name BETd-260 trifluoroacetate
CAS Number 2140289-21-8 Molecular Weight 912.928
Density N/A Boiling Point N/A
Molecular Formula C45H47F3N10O8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BETd-260 trifluoroacetate


BETd-260 trifluoroacetate (ZBC260, BETd 260 TFA) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL; effectively degrades BRD4 protein at 30 pM in the RS4;11 leukemia cell line, achieves an IC50 of 51 pM in inhibition of RS4;11 cell growth and induces rapid tumor regression in vivo against RS4;11 xenograft tumors.

 Names

Name BETd-260 trifluoroacetate

 BETd-260 trifluoroacetate Biological Activity

Description BETd-260 trifluoroacetate (ZBC260, BETd 260 TFA) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL; effectively degrades BRD4 protein at 30 pM in the RS4;11 leukemia cell line, achieves an IC50 of 51 pM in inhibition of RS4;11 cell growth and induces rapid tumor regression in vivo against RS4;11 xenograft tumors.
References References 1. Zhou B, et al. J Med Chem. 2017 Mar 24. doi: 10.1021/acs.jmedchem.6b01816. View Related Products by Target PROTAC

 Chemical & Physical Properties

Molecular Formula C45H47F3N10O8
Molecular Weight 912.928
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Chemsrc provides BETd-260 trifluoroacetate(CAS#:2140289-21-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of BETd-260 trifluoroacetate are included as well.>> amp version: BETd-260 trifluoroacetate

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