BETd-260 trifluoroacetate
Modify Date: 2024-05-10 13:40:51
BETd-260 trifluoroacetate structure
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Common Name | BETd-260 trifluoroacetate | ||
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| CAS Number | 2140289-21-8 | Molecular Weight | 912.928 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C45H47F3N10O8 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BETd-260 trifluoroacetateBETd-260 trifluoroacetate (ZBC260, BETd 260 TFA) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL; effectively degrades BRD4 protein at 30 pM in the RS4;11 leukemia cell line, achieves an IC50 of 51 pM in inhibition of RS4;11 cell growth and induces rapid tumor regression in vivo against RS4;11 xenograft tumors. |
| Name | BETd-260 trifluoroacetate |
|---|
| Description | BETd-260 trifluoroacetate (ZBC260, BETd 260 TFA) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL; effectively degrades BRD4 protein at 30 pM in the RS4;11 leukemia cell line, achieves an IC50 of 51 pM in inhibition of RS4;11 cell growth and induces rapid tumor regression in vivo against RS4;11 xenograft tumors. |
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| References | References 1. Zhou B, et al. J Med Chem. 2017 Mar 24. doi: 10.1021/acs.jmedchem.6b01816. View Related Products by Target PROTAC |
| Molecular Formula | C45H47F3N10O8 |
|---|---|
| Molecular Weight | 912.928 |