2140289-21-8

2140289-21-8 structure

Name: BETd-260 trifluoroacetate
Chemical Name: BETd-260 trifluoroacetate
CAS Number: 2140289-21-8
Molecular Formula: C₄₅H₄₇F₃N₁₀O₈
Molecular Weight: 912.928
Create Date: 2020-01-20 19:18:55
Modify Date: 2024-05-10 13:40:51
BETd-260 trifluoroacetate (ZBC260, BETd 260 TFA) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL; effectively degrades BRD4 protein at 30 pM in the RS4;11 leukemia cell line, achieves an IC50 of 51 pM in inhibition of RS4;11 cell growth and induces rapid tumor regression in vivo against RS4;11 xenograft tumors.

Name	BETd-260 trifluoroacetate

Description	BETd-260 trifluoroacetate (ZBC260, BETd 260 TFA) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL; effectively degrades BRD4 protein at 30 pM in the RS4;11 leukemia cell line, achieves an IC50 of 51 pM in inhibition of RS4;11 cell growth and induces rapid tumor regression in vivo against RS4;11 xenograft tumors.
References	References 1. Zhou B, et al. J Med Chem. 2017 Mar 24. doi: 10.1021/acs.jmedchem.6b01816. View Related Products by Target PROTAC

Molecular Formula	C₄₅H₄₇F₃N₁₀O₈
Molecular Weight	912.928