2140289-21-8
2140289-21-8 structure
- Name: BETd-260 trifluoroacetate
- Chemical Name: BETd-260 trifluoroacetate
- CAS Number: 2140289-21-8
- Molecular Formula: C45H47F3N10O8
- Molecular Weight: 912.928
- Create Date: 2020-01-20 19:18:55
- Modify Date: 2024-05-10 13:40:51
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BETd-260 trifluoroacetate (ZBC260, BETd 260 TFA) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL; effectively degrades BRD4 protein at 30 pM in the RS4;11 leukemia cell line, achieves an IC50 of 51 pM in inhibition of RS4;11 cell growth and induces rapid tumor regression in vivo against RS4;11 xenograft tumors.
| Name | BETd-260 trifluoroacetate |
|---|
| Description | BETd-260 trifluoroacetate (ZBC260, BETd 260 TFA) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL; effectively degrades BRD4 protein at 30 pM in the RS4;11 leukemia cell line, achieves an IC50 of 51 pM in inhibition of RS4;11 cell growth and induces rapid tumor regression in vivo against RS4;11 xenograft tumors. |
|---|---|
| References | References 1. Zhou B, et al. J Med Chem. 2017 Mar 24. doi: 10.1021/acs.jmedchem.6b01816. View Related Products by Target PROTAC |
| Molecular Formula | C45H47F3N10O8 |
|---|---|
| Molecular Weight | 912.928 |