TGR5 agonist 3

Modify Date: 2025-09-21 15:54:45

TGR5 agonist 3 Structure
TGR5 agonist 3 structure
Common Name TGR5 agonist 3
CAS Number 2148317-51-3 Molecular Weight 464.68
Density N/A Boiling Point N/A
Molecular Formula C28H48O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TGR5 agonist 3


TGR5 agonist 3 (compound 8), a Cholic acid derivative, is a selective TGR5 agonist with an EC50 of 5 μM[1].

 Names

Name TGR5 agonist 3

 TGR5 agonist 3 Biological Activity

Description TGR5 agonist 3 (compound 8), a Cholic acid derivative, is a selective TGR5 agonist with an EC50 of 5 μM[1].
Related Catalog
References

[1]. Emiliano Rosatelli, et al. Chemical exploration of TGR5 functional hot-spots: Synthesis and structure-activity relationships of C7- and C23-Substituted cholic acid derivatives. Eur J Med Chem. 2023 Oct 1:261:115851.  

 Chemical & Physical Properties

Molecular Formula C28H48O5
Molecular Weight 464.68

 TGR5 agonist 3Bioassay

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Name: Activation of GST-tagged FXR LBD (unknown origin) using biotinylated Src-1 peptide as...
Source: ChEMBL
Target: Bile acid receptor
External Id: CHEMBL5336740
Name: Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level i...
Source: ChEMBL
Target: G-protein coupled bile acid receptor 1
External Id: CHEMBL5336738
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