TGR5 agonist 3

Modify Date: 2026-06-30 18:29:52

TGR5 agonist 3 Structure
TGR5 agonist 3 structure
Common Name TGR5 agonist 3
CAS Number 2148317-51-3 Molecular Weight 464.68
Density N/A Boiling Point N/A
Molecular Formula C28H48O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TGR5 agonist 3


TGR5 agonist 3 (compound 8), a Cholic acid derivative, is a selective TGR5 agonist with an EC50 of 5 μM[1].

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name TGR5 agonist 3

 TGR5 agonist 3 Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description TGR5 agonist 3 (compound 8), a Cholic acid derivative, is a selective TGR5 agonist with an EC50 of 5 μM[1].
Related Catalog
References

[1]. Emiliano Rosatelli, et al. Chemical exploration of TGR5 functional hot-spots: Synthesis and structure-activity relationships of C7- and C23-Substituted cholic acid derivatives. Eur J Med Chem. 2023 Oct 1:261:115851.  

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Molecular Formula C28H48O5
Molecular Weight 464.68

 TGR5 agonist 3Bioassay

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This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Activation of GST-tagged FXR LBD (unknown origin) using biotinylated Src-1 peptide as...
Source: ChEMBL
Target: Bile acid receptor
External Id: CHEMBL5336740
Name: Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level i...
Source: ChEMBL
Target: G-protein coupled bile acid receptor 1
External Id: CHEMBL5336738
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 TGR5 agonist 3 | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the CAS number of TGR5 agonist 3?
A: CAS number of TGR5 agonist 3 is 2148317-51-3.
Q: What are the uses of TGR5 agonist 3?
A: Main uses of TGR5 agonist 3: TGR5 agonist 3 (compound 8), a Cholic acid derivative, is a selective TGR5 agonist with an EC50 of 5 μM[1].
Q: What is the molecular weight of TGR5 agonist 3?
A: Molecular weight of TGR5 agonist 3 is 464.68.
Q: What is the English name of TGR5 agonist 3?
A: The English name of TGR5 agonist 3 is TGR5 agonist 3.
Q: What is the Chinese name of 2148317-51-3?
A: Chinese name of 2148317-51-3 is 2148317-51-3.
Q: What is the molecular formula of TGR5 agonist 3?
A: Molecular formula of TGR5 agonist 3 is C28H48O5.
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