(R)-GSK-3685032
Modify Date: 2025-09-22 23:45:13
(R)-GSK-3685032 structure
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Common Name | (R)-GSK-3685032 | ||
|---|---|---|---|---|
| CAS Number | 2170140-50-6 | Molecular Weight | 420.53 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H24N6OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (R)-GSK-3685032(R)-GSK-3685032 is the R-enantiomer of GSK-3685032. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition[1][2]. |
| Name | (R)-GSK-3685032 |
|---|
| Description | (R)-GSK-3685032 is the R-enantiomer of GSK-3685032. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition[1][2]. |
|---|---|
| Related Catalog | |
| Target |
DNMT1 |
| References |
[1]. Substituted pyridines as inhibitors of DNMT1 and their preparation. WO2017216727. |
| Molecular Formula | C22H24N6OS |
|---|---|
| Molecular Weight | 420.53 |
| InChIKey | KNKHRZYILDZLRE-LJQANCHMSA-N |
| SMILES | CCc1c(C#N)c(SC(C(N)=O)c2ccccc2)nc(N2CCC(N)CC2)c1C#N |