Cyclo(-Arg-Gly-Asp-D-Tyr-Lys) trifluoroacetate salt

Modify Date: 2024-01-09 19:35:00

Cyclo(-Arg-Gly-Asp-D-Tyr-Lys) trifluoroacetate salt Structure
Cyclo(-Arg-Gly-Asp-D-Tyr-Lys) trifluoroacetate salt structure
Common Name Cyclo(-Arg-Gly-Asp-D-Tyr-Lys) trifluoroacetate salt
CAS Number 217099-14-4 Molecular Weight 619.67
Density N/A Boiling Point N/A
Molecular Formula C27H41N9O8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Cyclo(-Arg-Gly-Asp-D-Tyr-Lys) trifluoroacetate salt


Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.

 Names

Name CYCLO(-ARG-GLY-ASP-D-TYR-LYS)
Synonym More Synonyms

  Biological Activity

Description Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
Related Catalog
Target

IC50: 20 nM (αVβ3 Integrin), 3000 nM (αIIbβ3 Integrin), 4000 nM (αVβ5 Integrin)[1]

In Vitro Cyclo(RGDyK) (c(RGDyK(SAA)) shows high affinity and selectivity for αVβ3 over αVβ5 (IC50=4000 nM) and αIIbβ3 (IC50=3000 nM)[1].
References

[1]. Haubner R, et al. Glycosylated RGD-containing peptides: tracer for tumor targeting and angiogenesis imaging with improved biokinetics. J Nucl Med. 2001 Feb;42(2):326-36.

 Chemical & Physical Properties

Molecular Formula C27H41N9O8
Molecular Weight 619.67

 Synonyms

CYCLO (RGDYK)
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