Varenicline-d4

Modify Date: 2024-01-14 16:47:34

Varenicline-d4 structure	Common Name	Varenicline-d4
	CAS Number	2183239-01-0	Molecular Weight	215.29
	Density	1.2±0.1 g/cm3	Boiling Point	400.6±40.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₉D₄N₃	Melting Point	N/A
	MSDS	N/A	Flash Point	196.1±27.3 °C

Use of Varenicline-d4

Varenicline-d4 is deuterium labeled Varenicline. Varenicline (CP 526555) is a potent partial agonist for α4β2 nicotinic acetylcholine receptor (nAChR) with an EC50 value of 2.3 μM. Varenicline is a full agonist for α3β4 and α7 nAChRs with EC50 values of 55 μM and 18 μM, respectively[1]. Varenicline is a nicotinic ligand based on the structure of cytisine, has the potential for smoking cessation treatment[2].

Name	Varenicline-d4
Synonym	More Synonyms

Description	Varenicline-d4 is deuterium labeled Varenicline. Varenicline (CP 526555) is a potent partial agonist for α4β2 nicotinic acetylcholine receptor (nAChR) with an EC50 value of 2.3 μM. Varenicline is a full agonist for α3β4 and α7 nAChRs with EC50 values of 55 μM and 18 μM, respectively[1]. Varenicline is a nicotinic ligand based on the structure of cytisine, has the potential for smoking cessation treatment[2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Mihalak KB, et al. Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors.Mol Pharmacol. 2006 Sep;70(3):801-5. Epub 2006 Jun 9. [3]. Bagdas D, et al. New insights on the effects of varenicline on nicotine reward, withdrawal and hyperalgesia in mice.Neuropharmacology. 2018 Aug;138:72-79.

Density	1.2±0.1 g/cm3
Boiling Point	400.6±40.0 °C at 760 mmHg
Molecular Formula	C₁₃H₉D₄N₃
Molecular Weight	215.29
Flash Point	196.1±27.3 °C
Exact Mass	215.136047
LogP	0.74
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.667

(13,13,15,15-2H4)-5,8,14-Triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2,4(9),5,7,10-pentaene

Varenicline-d4

6,10-Methano-6H-azepino[4,5-g]quinoxaline-7,9-d2, 7,8,9,10-tetrahydro-7,9-d2-

Varenicline-d4

Use of Varenicline-d4

Names

Varenicline-d4 Biological Activity

Chemical & Physical Properties

Synonyms