Falcarinol

Modify Date: 2026-07-07 22:19:04

Falcarinol Structure
Falcarinol structure
Common Name Falcarinol
CAS Number 21852-80-2 Molecular Weight 244.372
Density 0.9±0.1 g/cm3 Boiling Point 370.6±42.0 °C at 760 mmHg
Molecular Formula C17H24O Melting Point N/A
MSDS N/A Flash Point 163.4±20.9 °C

 Use of Falcarinol


Falcarinol (Panaxynol) is a natural, orally active Hsp90 inhibitor targeting both the N-terminal and C-terminal of Hsp90 with limited toxicities. Falcarinol (Panaxynol) induces apoptosis[1].

 Names

Name 1,9-Heptadecadiene-4,6-diyn-3-ol
Synonym More Synonyms

 Falcarinol Biological Activity

Description Falcarinol (Panaxynol) is a natural, orally active Hsp90 inhibitor targeting both the N-terminal and C-terminal of Hsp90 with limited toxicities. Falcarinol (Panaxynol) induces apoptosis[1].
Related Catalog
In Vitro Panaxynol inhibits the sphere-forming ability of NSCLC CSCs by inducing apoptosis. Panaxynol suppresses the viability of NSCLC cells with no effects on normal cells[1].
References

[1]. Le HT, et al. Panaxynol, a natural Hsp90 inhibitor, effectively targets both lung cancer stem and non-stem cells. Cancer Lett. 2018 Jan 1;412:297-307.

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 370.6±42.0 °C at 760 mmHg
Molecular Formula C17H24O
Molecular Weight 244.372
Flash Point 163.4±20.9 °C
Exact Mass 244.182709
PSA 20.23000
LogP 6.96
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.507
InChIKey UGJAEDFOKNAMQD-QXPKXGMISA-N
SMILES C=CC(O)C#CC#CCC=CCCCCCCC

 Safety Information

HS Code 2905290000

 Synthetic Route

~69%

Falcarinol Structure

Falcarinol

CAS#:21852-80-2

Learn More
Literature: Mayer, Sandra F.; Steinreiber, Andreas; Orru, Romano V. A.; Faber, Kurt Journal of Organic Chemistry, 2002 , vol. 67, # 26 p. 9115 - 9121

~40%

Falcarinol Structure

Falcarinol

CAS#:21852-80-2

Learn More
Literature: McLaughlin, Noel P.; Butler, Eibhlin; Evans, Paul; Brunton, Nigel P.; Koidis, Anastasios; Rai, Dilip K. Tetrahedron, 2010 , vol. 66, # 51 p. 9681 - 9687

~%

Falcarinol Structure

Falcarinol

CAS#:21852-80-2

Learn More
Literature: Mayer, Sandra F.; Steinreiber, Andreas; Orru, Romano V. A.; Faber, Kurt Journal of Organic Chemistry, 2002 , vol. 67, # 26 p. 9115 - 9121

~%

Falcarinol Structure

Falcarinol

CAS#:21852-80-2

Learn More
Literature: Mayer, Sandra F.; Steinreiber, Andreas; Orru, Romano V. A.; Faber, Kurt Journal of Organic Chemistry, 2002 , vol. 67, # 26 p. 9115 - 9121

~%

Falcarinol Structure

Falcarinol

CAS#:21852-80-2

Learn More
Literature: Mayer, Sandra F.; Steinreiber, Andreas; Orru, Romano V. A.; Faber, Kurt Journal of Organic Chemistry, 2002 , vol. 67, # 26 p. 9115 - 9121

~%

Falcarinol Structure

Falcarinol

CAS#:21852-80-2

Learn More
Literature: Mayer, Sandra F.; Steinreiber, Andreas; Orru, Romano V. A.; Faber, Kurt Journal of Organic Chemistry, 2002 , vol. 67, # 26 p. 9115 - 9121

~%

Falcarinol Structure

Falcarinol

CAS#:21852-80-2

Learn More
Literature: Mayer, Sandra F.; Steinreiber, Andreas; Orru, Romano V. A.; Faber, Kurt Journal of Organic Chemistry, 2002 , vol. 67, # 26 p. 9115 - 9121

~%

Falcarinol Structure

Falcarinol

CAS#:21852-80-2

Learn More
Literature: Zheng, Guangrong; Lu, Wei; Aisa, Haji A.; Cai, Junchao Tetrahedron Letters, 1999 , vol. 40, # 11 p. 2181 - 2182

 Customs

HS Code 2905290000
Summary 2905290000 unsaturated monohydric alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 FalcarinolBioassay

View more

Name: Neuroprotective activity in rat PC12 cells assessed as reduction in NaN3-induced LDH ...
Source: ChEMBL
Target: PC-12
External Id: CHEMBL4829561
Name: Growth inhibition of human BT-549 cells after 48 hrs by SRB assay
Source: ChEMBL
Target: BT-549
External Id: CHEMBL4671944
Name: Irreversible inhibition of human alpha1c/beta2a/alpha2delta1 Cav1.2 expressed in HEK2...
Source: ChEMBL
Target: Voltage-dependent L-type calcium channel subunit alpha-1C
External Id: CHEMBL4829566
Name: Neuroprotective activity in rat PC12 cells assessed as reduction in NaN3-induced ROS ...
Source: ChEMBL
Target: PC-12
External Id: CHEMBL4829565
Name: Neuroprotective activity in rat PC12 cells assessed as reduction in NaN3-induced MDA ...
Source: ChEMBL
Target: PC-12
External Id: CHEMBL4829563
Name: Cytotoxicity against HEK293 cells assessed as cell viability at 3 uM after 18 hrs by ...
Source: ChEMBL
Target: HEK293
External Id: CHEMBL4611819
Name: Inhibitory activity against D-GalN-induced cytotoxicity in rat hepatocytes at 100 uM
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL787893
Name: Cytotoxicity against HEK293 cells assessed as cell viability at 10 uM after 24 hrs by...
Source: ChEMBL
Target: HEK293
External Id: CHEMBL4611820
Name: Growth inhibition of human MDA-MB-231 cells after 48 hrs by SRB assay
Source: ChEMBL
Target: MDA-MB-231
External Id: CHEMBL4671942
Name: Inhibitory activity against LPS-induced NO production in mouse peritoneal macrophages...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL741599
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 Synonyms

Carotatoxin
(-)-Falcarinol
(-)-Carotatoxin
(-)-Panaxynol
(−)-(3R)-falcarinol
(3R,9Z)-1,9-Heptadecadiene-4,6-diyn-3-ol
Falcarinol
Panaxynol
(3R,9Z)-Heptadeca-1,9-diene-4,6-diyn-3-ol
Falcarinol
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