Levetimide

Modify Date: 2024-01-09 11:00:39

Levetimide Structure
Levetimide structure
Common Name Levetimide
CAS Number 21888-99-3 Molecular Weight 362.46500
Density 1.178g/cm3 Boiling Point 543.9ºC at 760mmHg
Molecular Formula C23H26N2O2 Melting Point N/A
MSDS N/A Flash Point 282.7ºC

 Use of Levetimide


Levetimide is a potent and stereoselective inhibitor of [3H](+)pentazocine binding, with a Ki of 2.2 nM[1].

 Names

Name (3R)-1'-Benzyl-3-phenyl-3,4'-bipiperidine-2,6-dione

 Levetimide Biological Activity

Description Levetimide is a potent and stereoselective inhibitor of [3H](+)pentazocine binding, with a Ki of 2.2 nM[1].
Related Catalog
In Vitro Levetimide potently inhibits [3H]DTG binding although without stereoselectivity (Ki value of 103 nM) [1].
References

[1]. DeHaven-Hudkins DL, et al. Binding of dexetimide and levetimide to [3H](+)pentazocine- and [3H]1,3-di(2-tolyl)guanidine-defined sigma recognition sites. Life Sci. 1991;49(18):PL135-9.

 Chemical & Physical Properties

Density 1.178g/cm3
Boiling Point 543.9ºC at 760mmHg
Molecular Formula C23H26N2O2
Molecular Weight 362.46500
Flash Point 282.7ºC
Exact Mass 362.19900
PSA 52.90000
LogP 3.48700

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MA4029500
CHEMICAL NAME :
Glutarimide, 2-(1-benzyl-4-piperidyl)-2-phenyl-, (-)-
CAS REGISTRY NUMBER :
21888-99-3
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C23-H26-N2-O2
MOLECULAR WEIGHT :
362.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
38500 ug/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,1365,1971

 Safety Information

HS Code 2933399090

 Synthetic Route

~%

Levetimide Structure

Levetimide

CAS#:21888-99-3

Literature: JANSSEN PHARMACEUTICA N.V. Patent: WO2007/90826 A1, 2007 ; Location in patent: Page/Page column 65 ; WO 2007/090826 A1

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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