21888-99-3

21888-99-3 structure

21888-99-3 structure

Name: Levetimide
Chemical Name: (3R)-1'-Benzyl-3-phenyl-3,4'-bipiperidine-2,6-dione
CAS Number: 21888-99-3
Molecular Formula: C₂₃H₂₆N₂O₂
Molecular Weight: 362.46500
Catalog: Signaling Pathways GPCR/G Protein mAChR
Create Date: 2018-06-21 17:58:31
Modify Date: 2024-01-09 11:00:39
Levetimide is a potent and stereoselective inhibitor of [3H](+)pentazocine binding, with a Ki of 2.2 nM[1].

Name	(3R)-1'-Benzyl-3-phenyl-3,4'-bipiperidine-2,6-dione

Description	Levetimide is a potent and stereoselective inhibitor of [3H](+)pentazocine binding, with a Ki of 2.2 nM[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
In Vitro	Levetimide potently inhibits [3H]DTG binding although without stereoselectivity (Ki value of 103 nM) [1].
References	[1]. DeHaven-Hudkins DL, et al. Binding of dexetimide and levetimide to [3H](+)pentazocine- and [3H]1,3-di(2-tolyl)guanidine-defined sigma recognition sites. Life Sci. 1991;49(18):PL135-9.

Density	1.178g/cm3
Boiling Point	543.9ºC at 760mmHg
Molecular Formula	C₂₃H₂₆N₂O₂
Molecular Weight	362.46500
Flash Point	282.7ºC
Exact Mass	362.19900
PSA	52.90000
LogP	3.48700

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MA4029500

CHEMICAL NAME :: Glutarimide, 2-(1-benzyl-4-piperidyl)-2-phenyl-, (-)-

CAS REGISTRY NUMBER :: 21888-99-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C23-H26-N2-O2

MOLECULAR WEIGHT :: 362.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 38500 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,1365,1971

HS Code	2933399090

14051-33-3 structure

14051-33-3

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21888-98-2 structure

21888-98-2

21888-99-3 structure

21888-99-3

Literature: JANSSEN PHARMACEUTICA N.V. Patent: WO2007/90826 A1, 2007 ; Location in patent: Page/Page column 65 ; WO 2007/090826 A1

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%