4-Pyridinecarbothioamide

Modify Date: 2026-08-09 23:38:26

4-Pyridinecarbothioamide structure	Common Name	4-Pyridinecarbothioamide
	CAS Number	2196-13-6	Molecular Weight	138.190
	Density	1.3±0.1 g/cm3	Boiling Point	278.9±32.0 °C at 760 mmHg
	Molecular Formula	C₆H₆N₂S	Melting Point	201 °C
	MSDS	Chinese USA	Flash Point	122.5±25.1 °C
	Symbol	GHS07	Signal Word	Warning

Use of 4-Pyridinecarbothioamide

Thioisonicotinamide (4-Pyridylthioamide) is a synthetic intermediate used for pharmaceutical synthesis.

Name	pyridine-4-carbothioamide
Synonym	More Synonyms

Description	Thioisonicotinamide (4-Pyridylthioamide) is a synthetic intermediate used for pharmaceutical synthesis.
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others

Density	1.3±0.1 g/cm3
Boiling Point	278.9±32.0 °C at 760 mmHg
Melting Point	201 °C
Molecular Formula	C₆H₆N₂S
Molecular Weight	138.190
Flash Point	122.5±25.1 °C
Exact Mass	138.025162
PSA	71.00000
LogP	0.23
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.664
InChIKey	KPIIGXWUNXGGCP-UHFFFAOYSA-N
SMILES	NC(=S)c1ccncc1

4-Pyridinecarbothioamide MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US4204000

CHEMICAL NAME :: 4-Pyridinecarbothioamide

CAS REGISTRY NUMBER :: 2196-13-6

BEILSTEIN REFERENCE NO. :: 0002174

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H6-N2-S

MOLECULAR WEIGHT :: 138.20

WISWESSER LINE NOTATION :: T6NJ DYZUS

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOCEAH Journal of Organic Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1936- Volume(issue)/page/year: 19,753,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	20/21/22-42/43-36/37/38-22
Safety Phrases	S26-S36/37/39
RIDADR	NONH for all modes of transport
RTECS	US4204000
HS Code	2933399090

Isonicotinamide

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Literature: Martelli, Alma; Testai, Lara; Citi, Valentina; Marino, Alice; Pugliesi, Isabella; Barresi, Elisabetta; Nesi, Giulia; Rapposelli, Simona; Taliani, Sabrina; Da Settimo, Federico; Breschi, Maria C.; Calderone, Vincenzo ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 10 p. 904 - 908

Isonicotinonitrile

CAS#:100-48-1

~96%

4-Pyridinecarbo...

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Literature: Khosropour; Noei; Mirjafari Journal of the Iranian Chemical Society, 2010 , vol. 7, # 3 p. 752 - 758

4-Pyridinealdoxime

CAS#:696-54-8

~80%

4-Pyridinecarbo...

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Literature: Noei, Jalil; Khosropour, Ahmad R. Tetrahedron Letters, 2008 , vol. 49, # 49 p. 6969 - 6971

dithioisonicoti...

CAS#:108103-05-5

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Literature: Chemische Berichte, , vol. 87, p. 825,834

p-Formylpyridine

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Literature: Synthetic Communications, , vol. 44, # 3 p. 408 - 416

Precursor 5
CAS#:1453-82-3 Isonicotinamide CAS#:100-48-1 Isonicotinonitrile CAS#:696-54-8 4-Pyridinealdoxime CAS#:108103-05-5 dithioisonicoti...
CAS#:872-85-5 p-Formylpyridine
DownStream 10
CAS#:106950-18-9 4-Phenyl-2-(4-p... CAS#:3731-53-1 4-picolinylamine CAS#:1822-53-3 4-Pyridinylmeth... CAS#:21346-36-1 2-(pyridin-4-yl...
CAS#:21278-85-3 2-(4-pyridinyl)... CAS#:100-48-1 Isonicotinonitrile CAS#:581-47-5 2,4-bipyridyl CAS#:15311-09-8 Pyridine,4,4'-(...
CAS#:89830-71-7 N'-aminopyridin... CAS#:1453-82-3 Isonicotinamide

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Name: Inhibition of mushroom tyrosinase using L-tyrosine as substrate
Source: ChEMBL
Target: Polyphenol oxidase 2
External Id: CHEMBL3743599

Name: Induction of H2S release in PBS buffer 10x at pH 7.4 assessed as time required to rea...
Source: ChEMBL
Target: N/A
External Id: CHEMBL2444679

Name: Induction of H2S release in PBS buffer 10x at pH 7.4 assessed as maximal concentratio...
Source: ChEMBL
Target: N/A
External Id: CHEMBL2444678

Name: Induction of H2S release in PBS buffer 10x at pH 7.4 assessed as maximal concentratio...
Source: ChEMBL
Target: N/A
External Id: CHEMBL2444677

Name: Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction of melanin produ...
Source: ChEMBL
Target: Tyrosinase
External Id: CHEMBL3743604

Name: Cytotoxicity against mouse B16F10 cells assessed as cell survival at 50 uM after 48 h...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3743603

Name: Binding affinity to mushroom tyrosinase assessed as fluorescence quenching
Source: ChEMBL
Target: Polyphenol oxidase 2
External Id: CHEMBL3743602

Name: Non-competitive inhibition of mushroom tyrosinase using L-tyrosine as substrate by Li...
Source: ChEMBL
Target: Polyphenol oxidase 2
External Id: CHEMBL3743601

Name: Inhibition of tyrosinase in mouse B16F10 cell lysates using DOPA as substrate relativ...
Source: ChEMBL
Target: Tyrosinase
External Id: CHEMBL3743607

Name: Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction of melanin produ...
Source: ChEMBL
Target: Tyrosinase
External Id: CHEMBL3743606

Total 12, Current Page 1 of 2

Isonicotinic acid thioamide

4-thiocarbamoylpyridine

Thioisonicotinamide

pyridine-4-carbothioamide

4-Pyridylthioamide

Thio-4-pyridinecarboxamide

4-Pyridylthiocarboxamide

Isonicotinamide,thio

EINECS 218-592-6

Isothionicotinamide

4-Pyridinecarbothioamide

MFCD00006437

pyridine-4-thioamide

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 4-Pyridinecarbothioamide
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Thioisonicotinamide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: ￥500/100 mg

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4-Pyridinecarbothioamide

Use of 4-Pyridinecarbothioamide

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