MP A08
Modify Date: 2024-01-13 14:04:29
MP A08 structure
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Common Name | MP A08 | ||
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| CAS Number | 219832-49-2 | Molecular Weight | 519.635 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 717.1±70.0 °C at 760 mmHg | |
| Molecular Formula | C27H25N3O4S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 387.5±35.7 °C | |
Use of MP A08MP-A08 is a highly selective ATP competitive sphingosine kinase (SK) inhibitor that targets both SphK1 and SphK2 with Kivalues of 6.9 ± 0.8 μM and 27 ± 3 μM, respectively.In vitro:MP-A08 blocks pro-proliferative signalling pathways, induces mitochondrial-associated apoptosis in a SK-dependent manner, and reduces the growth of human lung adenocarcinoma tumours in a mouse xenograft model by both inducing tumour cell apoptosis and inhibiting tumour angiogenesis. MP-A08 inhibit SphK2, cause a decrease in EC barrier integrity in vitro in both cell type.[2]In vivo: MP-A08 suppresses the growth of human lung tumor xenografts in mice. |
| Name | MP-A08 |
|---|---|
| Synonym | More Synonyms |
| Description | MP-A08 is a highly selective ATP competitive sphingosine kinase (SK) inhibitor that targets both SphK1 and SphK2 with Kivalues of 6.9 ± 0.8 μM and 27 ± 3 μM, respectively.In vitro:MP-A08 blocks pro-proliferative signalling pathways, induces mitochondrial-associated apoptosis in a SK-dependent manner, and reduces the growth of human lung adenocarcinoma tumours in a mouse xenograft model by both inducing tumour cell apoptosis and inhibiting tumour angiogenesis. MP-A08 inhibit SphK2, cause a decrease in EC barrier integrity in vitro in both cell type.[2]In vivo: MP-A08 suppresses the growth of human lung tumor xenografts in mice. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 717.1±70.0 °C at 760 mmHg |
| Molecular Formula | C27H25N3O4S2 |
| Molecular Weight | 519.635 |
| Flash Point | 387.5±35.7 °C |
| Exact Mass | 519.128662 |
| LogP | 5.31 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.634 |
| Storage condition | 2-8℃ |
| 4-Methyl-N-{2-[(E)-(2-{[(4-methylphenyl)sulfonyl]amino}benzylidene)amino]phenyl}benzenesulfonamide |
| Benzenesulfonamide, 4-methyl-N-[2-[(E)-[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]- |