Isoescin IB

Modify Date: 2024-01-08 17:58:19

Isoescin IB Structure
Isoescin IB structure
Common Name Isoescin IB
CAS Number 219944-46-4 Molecular Weight 1131.257
Density 1.5±0.1 g/cm3 Boiling Point 1148.1±65.0 °C at 760 mmHg
Molecular Formula C55H86O24 Melting Point N/A
MSDS N/A Flash Point 314.2±27.8 °C

 Use of Isoescin IB


Isoescin IB, isolated from horse chestnut tree seeds, is an isomer of Escin IB. Isoescin IB and Escin IB are the chief active ingredients in escin[1].

 Names

Name (3β,16α,21β,22α)-28-Acetoxy-16,22,24-trihydroxy-21-{[(2Z)-2-methylbut-2-enoyl]oxy}olean-12-en-3-yl β-D-glucopyranosyl-(1->2)-[β-D-glucopyranosyl-(1->4)]-β-D-glucopyranosiduronic acid
Synonym More Synonyms

 Isoescin IB Biological Activity

Description Isoescin IB, isolated from horse chestnut tree seeds, is an isomer of Escin IB. Isoescin IB and Escin IB are the chief active ingredients in escin[1].
Related Catalog
In Vitro β-Escin (mainly consisting of escin Ia and escin Ib) is the major active ingredient in horse chestnut seeds extracts. β-escin can inhibit proliferation and/or induce apoptosis in various types of cancer cells including A549 cell, HT-29 cell, HCC cell, OVCAR3 cell and H-Ras 5RP7 cell. β-escin may be useful as a chemopreventive agent, especially for tumors associated with an inflammatory response[1]. As the minor component of escin, α-escin (mainly consisting of isoescin Ia and isoescin Ib) exhibits lower bioactivity[1].
References

[1]. Wu XJ, et al. Comparative pharmacokinetics and the bioavailability of escin Ib and isoescin Ib following the administration of escin, pure escin Ib and isoescin Ib in rats.J Ethnopharmacol. 2014 Feb 3;151(2):839-45.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 1148.1±65.0 °C at 760 mmHg
Molecular Formula C55H86O24
Molecular Weight 1131.257
Flash Point 314.2±27.8 °C
Exact Mass 1130.550903
LogP 2.17
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.628

 Synonyms

2-butenoic acid, 2-methyl-, (3β,16α,21β,22α)-28-(acetyloxy)-3-[[O-β-D-glucopyranosyl-(1->2)-O-[β-D-glucopyranosyl-(1->4)]-β-D-glucopyranuronosyl]oxy]-16,22,24-trihydroxyolean-12-en-21-yl ester, (2Z)-
(3β,16α,21β,22α)-28-Acetoxy-16,22,24-trihydroxy-21-{[(2Z)-2-methylbut-2-enoyl]oxy}olean-12-en-3-yl β-D-glucopyranosyl-(1->2)-[β-D-glucopyranosyl-(1->4)]-β-D-glucopyranosiduronic acid
2-Butenoic acid, 2-methyl-, (3β,16α,21β,22α)-28-(acetyloxy)-3-[[O-β-D-glucopyranosyl-(1->2)-O-[β-D-glucopyranosyl-(1->4)]-β-D-glucopyranuronosyl]oxy]-16,22,24-trihydroxyolean-12 
-en-21-yl ester, (2Z)-
Aescin D
Escin IVb
Isoescin Ib
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