licopyranocoumarin
Modify Date: 2025-08-21 08:23:14
licopyranocoumarin structure
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Common Name | licopyranocoumarin | ||
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| CAS Number | 117038-80-9 | Molecular Weight | 384.37900 | |
| Density | 1.397g/cm3 | Boiling Point | 675.3ºC at 760mmHg | |
| Molecular Formula | C21H20O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 242.9ºC | |
Use of licopyranocoumarinLicopyranocoumarin is an isoflavonoid that shows CYP3A4 inhibitory activity with an IC50 of 32 μM. Licopyranocoumarin has potent neuroprotective activities[1]. |
| Name | 3-(2,4-Dihydroxyphenyl)-8-(hydroxymethyl)-5-methoxy-8-methyl-7,8- dihydro-2H,6H-pyrano[3,2-g]chromen-2-one |
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| Synonym | More Synonyms |
| Description | Licopyranocoumarin is an isoflavonoid that shows CYP3A4 inhibitory activity with an IC50 of 32 μM. Licopyranocoumarin has potent neuroprotective activities[1]. |
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| Related Catalog | |
| Target |
CYP3A4:32 μM (IC50) |
| In Vitro | Licopyranocoumarin（0.3-3 μM；48 小时）显着阻断 MPP+ 诱导的神经元 PC12D 细胞死亡和线粒体膜电位消失，这是由 JNK[1] 介导的。 Licopyranocoumarin（0.3-3 μM；36 小时）通过抑制活性氧 (ROS) 的生成来抑制 MPP+ 诱导的 JNK 活化，从而抑制 MPP+ 诱导的神经元 PC12D 细胞死亡[1]。 Cell Viability Assay[1] Cell Line: PC12D cell Concentration: 0.3 μM, 1 μM, 3 μM Incubation Time: 48 hours Result: Inhibited MPP+-induced cell death. Western Blot Analysis[1] Cell Line: PC12D cell Concentration: 0.3 μM, 1 μM, 3 μM Incubation Time: 36 hours Result: Attenuated JNK activity induced by MPP+. |
| References |
| Density | 1.397g/cm3 |
|---|---|
| Boiling Point | 675.3ºC at 760mmHg |
| Molecular Formula | C21H20O7 |
| Molecular Weight | 384.37900 |
| Flash Point | 242.9ºC |
| Exact Mass | 384.12100 |
| PSA | 109.36000 |
| LogP | 2.95580 |
| Vapour Pressure | 3.68E-19mmHg at 25°C |
| Index of Refraction | 1.641 |
| Hazard Codes | Xi |
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| IB-MECA |
| 3-IB-Meca |
| CF 101 |