(1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylic acid

Modify Date: 2024-01-04 16:26:08

(1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylic acid Structure
(1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylic acid structure
Common Name (1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylic acid
CAS Number 220352-36-3 Molecular Weight 198.166
Density 1.4±0.1 g/cm3 Boiling Point 308.1±42.0 °C at 760 mmHg
Molecular Formula C10H8F2O2 Melting Point N/A
MSDS N/A Flash Point 140.1±27.9 °C

 Names

Name (1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylic acid
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 308.1±42.0 °C at 760 mmHg
Molecular Formula C10H8F2O2
Molecular Weight 198.166
Flash Point 140.1±27.9 °C
Exact Mass 198.049240
PSA 37.30000
LogP 1.74
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.556

 Safety Information

Hazard Codes Xi

 Synthetic Route

~96%

(1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylic acid Structure

(1R,2R)-2-(3,4-...

CAS#:220352-36-3

Literature: ASTRAZENECA AB Patent: WO2008/18823 A1, 2008 ; Location in patent: Page/Page column 30-31 ; WO 2008/018823 A1

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(1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylic acid Structure

(1R,2R)-2-(3,4-...

CAS#:220352-36-3

Literature: ACTAVIS GROUP PTC EHF; Khile, Anil Shahaji; Nair, Vignesh; Trivedi, Nikhil; Pradhan, Nitin Sharadchandra Patent: US2013/165696 A1, 2013 ;

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(1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylic acid Structure

(1R,2R)-2-(3,4-...

CAS#:220352-36-3

Literature: ACTAVIS GROUP PTC EHF; Khile, Anil Shahaji; Nair, Vignesh; Trivedi, Nikhil; Pradhan, Nitin Sharadchandra Patent: US2013/165696 A1, 2013 ;

~%

(1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylic acid Structure

(1R,2R)-2-(3,4-...

CAS#:220352-36-3

Literature: AUSPEX PHARMACEUTICALS, INC.; RAO, Tadimeti; ZHANG, Chengzhi Patent: WO2011/17108 A2, 2011 ; WO 2011/017108 A2

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(1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylic acid Structure

(1R,2R)-2-(3,4-...

CAS#:220352-36-3

Literature: AUSPEX PHARMACEUTICALS, INC.; RAO, Tadimeti; ZHANG, Chengzhi Patent: WO2011/17108 A2, 2011 ; WO 2011/017108 A2

~%

(1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylic acid Structure

(1R,2R)-2-(3,4-...

CAS#:220352-36-3

Literature: Zhang, Hao; Liu, Jun; Zhang, Luyong; Kong, Lingyi; Yao, Hequan; Sun, Hongbin Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 11 p. 3598 - 3602

~%

(1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylic acid Structure

(1R,2R)-2-(3,4-...

CAS#:220352-36-3

Literature: Zhang, Hao; Liu, Jun; Zhang, Luyong; Kong, Lingyi; Yao, Hequan; Sun, Hongbin Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 11 p. 3598 - 3602

~%

(1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylic acid Structure

(1R,2R)-2-(3,4-...

CAS#:220352-36-3

Literature: Zhang, Hao; Liu, Jun; Zhang, Luyong; Kong, Lingyi; Yao, Hequan; Sun, Hongbin Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 11 p. 3598 - 3602

~%

(1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylic acid Structure

(1R,2R)-2-(3,4-...

CAS#:220352-36-3

Literature: Zhang, Hao; Liu, Jun; Zhang, Luyong; Kong, Lingyi; Yao, Hequan; Sun, Hongbin Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 11 p. 3598 - 3602

 Synonyms

trans-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid
trans-(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid
(1R,2R)-trans-2-(3,4-difluorophenyl)-1-cyclopropanecarboxylic acid
(1R-trans)-2-(3,4-difluorophenyl)-cyclopropanecarboxylic acid
Cyclopropanecarboxylic acid, 2-(3,4-difluorophenyl)-, (1R,2R)-
(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylic acid
(1R,2R)-2-(3,4-difluorophenyl)-1-cyclopropanecarboxylic acid
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