p-MPPI hydrochloride

Modify Date: 2025-08-25 16:03:22

p-MPPI hydrochloride structure	Common Name	p-MPPI hydrochloride
	CAS Number	220643-77-6	Molecular Weight	578.87300
	Density	N/A	Boiling Point	657.5ºC at 760 mmHg
	Molecular Formula	C₂₅H₂₈ClIN₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	351.4ºC

Use of p-MPPI hydrochloride

p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with high affinity for 5-HT1A receptors. p-MPPI hydrochloride can crosses the blood-brain barrier, and has clear antidepressant and anxiolytic-like effects[1][2].

Name	4-iodo-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-pyridin-2-ylbenzamide,hydrochloride
Synonym	More Synonyms

Description	p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with high affinity for 5-HT1A receptors. p-MPPI hydrochloride can crosses the blood-brain barrier, and has clear antidepressant and anxiolytic-like effects[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT1A Receptor
In Vitro	p-MPPI hydrochloride has no agonist activity in both in vitro and in vivo tests of pre- and post-synaptic 5-HT1A receptor activity[1].
In Vivo	p-MPPI hydrochloride (0.5-4.5 mg/kg; i.p.) shows anxiolytic-like profile in the murine elevated plus-maze[2]. Animal Model: Adult male Swiss Webster mice (aged 8-9 weeks)[2] Dosage: 0.5, 1.5, 4.5 mg/kg Administration: i.p. Result: Produced a significant and dose-related anxiolytic profile on both conventional (open arm avoidance) and ethological (risk assessment) measures.
References	[1]. Sørensen E, et al. The selective 5-HT(1A) receptor antagonist p-MPPI antagonizes sleep--waking and behavioural effects of 8-OH-DPAT in rats. Behav Brain Res. 2001 Jun;121(1-2):181-7. [2]. Cao BJ, et al. Anxiolytic-like profile of p-MPPI, a novel 5HT1A receptor antagonist, in the murine elevated plus-maze. Psychopharmacology (Berl). 1997 Feb;129(4):365-71.

Boiling Point	657.5ºC at 760 mmHg
Molecular Formula	C₂₅H₂₈ClIN₄O₂
Molecular Weight	578.87300
Flash Point	351.4ºC
Exact Mass	578.09500
PSA	48.91000
LogP	4.96870
Vapour Pressure	3.66E-17mmHg at 25°C

p-MPPI hydrochloride MSDS(Chinese)

Hazard Codes	Xi

4-Iodo-N-[2-[4-(methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)benzamide monohydrochloride

P-Mppi HCl

p-MPPI hydrochloride

p-MPPI monohydrochloride

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China
Product Name: p-MPPI hydrochloride
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China
Product Name: p-MPPI hydrochloride
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DC Chemicals Limited
China
Product Name: p-MPPI hydrochloride
Price: $350.0/100mg $550.0/250mg $1100.0/1g
Purity: 98.0%
Delivery: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: P-MPPI MONOHYDROCHLORIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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p-MPPI hydrochloride

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