(D-Phe11,His12)-Sauvagine (11-40)

Modify Date: 2024-01-04 04:44:59

(D-Phe11,His12)-Sauvagine (11-40) Structure
(D-Phe11,His12)-Sauvagine (11-40) structure
 Common Name (D-Phe11,His12)-Sauvagine (11-40)
CAS Number 220673-95-0 Molecular Weight 3651.24000
Density N/A Boiling Point N/A
Molecular Formula C161H274N48O46S Melting Point N/A
MSDS USA Flash Point N/A

 Use of (D-Phe11,His12)-Sauvagine (11-40)


Antisauvagine-30 (aSvg-30) is a potent, competitive and selective CRF2 receptor antagonist with Kd values of 1.4 nM and 153.6 nM for mouse CRF2β and rat CRF1 receptors, respectively[1].

 Names

Name Antisauvagine-30
Synonym More Synonyms

 (D-Phe11,His12)-Sauvagine (11-40) Biological Activity

Description Antisauvagine-30 (aSvg-30) is a potent, competitive and selective CRF2 receptor antagonist with Kd values of 1.4 nM and 153.6 nM for mouse CRF2β and rat CRF1 receptors, respectively[1].
Related Catalog
Target

Kd: 1.4 nM (mouse CRF2β) ;Kd: 153.6 nM (rat CRF1)[1]

References

[1]. O Brauns, et al. Pharmacological and chemical properties of astressin, antisauvagine-30 and alpha-helCRF: significance for behavioral experiments. Neuropharmacology. 2001 Sep;41(4):507-16.

[2]. Farahnaz Sananbenesi, et al. Mitogen-activated protein kinase signaling in the hippocampus and its modulation by corticotropin-releasing factor receptor 2: a possible link between stress and fear memory. J Neurosci

 Chemical & Physical Properties

Molecular Formula C161H274N48O46S
Molecular Weight 3651.24000
Exact Mass 3649.01000
PSA 1611.26000
LogP 8.45320

 Safety Information

Safety Phrases 22-24/25
WGK Germany 3

 Synonyms

H-D-Phe-His-Leu-Leu-Arg-Lys-Met-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ile-NH2
D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THR-ILE-NH2
H-D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THE-ILE-OH
M.W. 3650.29 C161H274N48O46S
Antisauvagine 30
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Chemsrc provides (D-Phe11,His12)-Sauvagine (11-40)(CAS#:220673-95-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of (D-Phe11,His12)-Sauvagine (11-40) are included as well.>> amp version: (D-Phe11,His12)-Sauvagine (11-40)

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