tert-Butyl 11-aminoundecanoate

Modify Date: 2024-01-12 20:28:45

tert-Butyl 11-aminoundecanoate Structure
tert-Butyl 11-aminoundecanoate structure
Common Name tert-Butyl 11-aminoundecanoate
CAS Number 220851-29-6 Molecular Weight 257.41200
Density N/A Boiling Point N/A
Molecular Formula C15H31NO2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of tert-Butyl 11-aminoundecanoate


tert-Butyl 11-aminoundecanoate (compound 6b) is a PROTAC linker, which refers to the PEG composition. tert-Butyl 11-aminoundecanoate can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

 Names

Name tert-butyl 11-aminoundecanoate
Synonym More Synonyms

 tert-Butyl 11-aminoundecanoate Biological Activity

Description tert-Butyl 11-aminoundecanoate (compound 6b) is a PROTAC linker, which refers to the PEG composition. tert-Butyl 11-aminoundecanoate can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Related Catalog
Target

PEGs

References

[1]. Kim K, et al. Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera. Sci Rep. 2019 Dec 23;9(1):19654.

 Chemical & Physical Properties

Molecular Formula C15H31NO2
Molecular Weight 257.41200
Exact Mass 257.23500
PSA 52.32000
LogP 4.49800
Storage condition -20°C

 Safety Information

Hazard Codes C

 Synonyms

MFCD31729305