JH-XI-10-02
Modify Date: 2025-08-27 12:09:54
JH-XI-10-02 structure
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Common Name | JH-XI-10-02 | ||
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| CAS Number | 2209085-22-1 | Molecular Weight | 920.14 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C53H69N5O9 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JH-XI-10-02JH-XI-10-02 is a potent and selective degrader of CDK8, with an IC50 of 159 nM, based on PROTAC. JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19[1]. |
| Name | JH-XI-10-02 |
|---|
| Description | JH-XI-10-02 is a potent and selective degrader of CDK8, with an IC50 of 159 nM, based on PROTAC. JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19[1]. |
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| Related Catalog | |
| Target |
CDK8:159 nM (IC50) PROTAC |
| References |
| Molecular Formula | C53H69N5O9 |
|---|---|
| Molecular Weight | 920.14 |
| InChIKey | JECHBTRAPARMGI-WIJLIHDRSA-N |
| SMILES | CN(C(=O)CCOCCOCCOCCOCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)C1CCC2(C)C(CCC3C2CCC2(C)C(c4ccc5ccncc5c4)CCC32)C1 |
| Hazard Codes | Xi |
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