elomotecan

Modify Date: 2024-01-11 15:37:25

elomotecan Structure
elomotecan structure
Common Name elomotecan
CAS Number 220998-10-7 Molecular Weight 522.035
Density 1.4±0.1 g/cm3 Boiling Point 821.3±65.0 °C at 760 mmHg
Molecular Formula C29H32ClN3O4 Melting Point N/A
MSDS N/A Flash Point 450.5±34.3 °C

 Use of elomotecan


Elomotecan (BN 80927 free base) is a potent inhibitor of topoisomerases I and II. Elomotecan is a camptothecin analog belonging to the homocamptothecin family (hCPT). Elomotecan reduces the proliferation of different tumor cells with higher potency than other anticancer drugs of reference targeting topoisomerases I and II[1].

 Names

Name Elomotecan
Synonym More Synonyms

 elomotecan Biological Activity

Description Elomotecan (BN 80927 free base) is a potent inhibitor of topoisomerases I and II. Elomotecan is a camptothecin analog belonging to the homocamptothecin family (hCPT). Elomotecan reduces the proliferation of different tumor cells with higher potency than other anticancer drugs of reference targeting topoisomerases I and II[1].
Related Catalog
Target

Topoisomerase I

Topoisomerase II

References

[1]. Trocóniz IF, et al. Population pharmacokinetic/pharmacodynamic modeling of drug-induced adverse effects of a novel homocamptothecin analog, elomotecan (BN80927), in a Phase I dose finding study in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2012;70(2):239-250.  

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 821.3±65.0 °C at 760 mmHg
Molecular Formula C29H32ClN3O4
Molecular Weight 522.035
Flash Point 450.5±34.3 °C
Exact Mass 521.208130
PSA 84.66000
LogP 3.98
Vapour Pressure 0.0±3.1 mmHg at 25°C
Index of Refraction 1.684

 Synonyms

3H,15H-Oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione, 9-chloro-5-ethyl-1,4,5,13-tetrahydro-5-hydroxy-10-methyl-12-[(4-methyl-1-piperidinyl)methyl]-, (5R)-
unii-44ka9q75gt
elomotecan
(5R)-9-Chloro-5-ethyl-5-hydroxy-10-methyl-12-[(4-methyl-1-piperidinyl)methyl]-1,4,5,13-tetrahydro-3H,15H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione
Top Suppliers:I want be here

Get all suppliers and price by the below link:

elomotecan suppliers

elomotecan price