Chloromethyl chloroformate

Modify Date: 2025-08-21 09:41:52

Chloromethyl chloroformate Structure
Chloromethyl chloroformate structure
Common Name Chloromethyl chloroformate
CAS Number 22128-62-7 Molecular Weight 128.942
Density 1.5±0.1 g/cm3 Boiling Point 107.9±13.0 °C at 760 mmHg
Molecular Formula C2H2Cl2O2 Melting Point <-20ºC
MSDS Chinese USA Flash Point 25.5±15.2 °C
Symbol GHS05 GHS06
GHS05, GHS06
Signal Word Danger

 Names

Name chloromethyl carbonochloridate
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 107.9±13.0 °C at 760 mmHg
Melting Point <-20ºC
Molecular Formula C2H2Cl2O2
Molecular Weight 128.942
Flash Point 25.5±15.2 °C
Exact Mass 127.943184
PSA 26.30000
LogP 1.14
Vapour Pressure 26.5±0.2 mmHg at 25°C
Index of Refraction 1.432

 Safety Information

Symbol GHS05 GHS06
GHS05, GHS06
Signal Word Danger
Hazard Statements H314-H331
Precautionary Statements P261-P280-P305 + P351 + P338-P310
Personal Protective Equipment Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes T:Toxic;
Risk Phrases R23;R34
Safety Phrases S26-S36/37/39-S45
RIDADR UN 2745 6.1/PG 2
WGK Germany 3
Packaging Group II
Hazard Class 6.1

 Synthetic Route

~22%

Chloromethyl chloroformate Structure

Chloromethyl ch...

CAS#:22128-62-7

Literature: Folkmann; Lund Synthesis, 1990 , # 12 p. 1159 - 1166

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Chloromethyl chloroformate Structure

Chloromethyl ch...

CAS#:22128-62-7

Literature: Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, , vol. 169, p. 1047 Annales de Chimie (Cachan, France), , vol. <9>13, p. 47 Journal fuer Praktische Chemie (Leipzig), , vol. <2>36, p. 104,212,470 Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, , vol. 169, p. 1075 Annales de Chimie (Cachan, France), , vol. <9>13, p. 246 Journal of Physical Chemistry, , vol. 23, p. 509 Chem. Zentralbl., , vol. 91, # I p. 197

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Chloromethyl chloroformate Structure

Chloromethyl ch...

CAS#:22128-62-7

Literature: Journal of Molecular Structure, , vol. 198, p. 239 - 266

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Chloromethyl chloroformate Structure

Chloromethyl ch...

CAS#:22128-62-7

Literature: Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, , vol. 169, p. 1146 Annales de Chimie (Cachan, France), , vol. <9>13, p. 259 Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, , vol. 169, p. 1047 Annales de Chimie (Cachan, France), , vol. <9>13, p. 47 Journal of Physical Chemistry, , vol. 23, p. 509 Chem. Zentralbl., , vol. 91, # I p. 197

~%

Chloromethyl chloroformate Structure

Chloromethyl ch...

CAS#:22128-62-7

Literature: Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, , vol. 169, p. 1047 Annales de Chimie (Cachan, France), , vol. <9>13, p. 47 Journal fuer Praktische Chemie (Leipzig), , vol. <2>36, p. 104,212,470 Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, , vol. 169, p. 1075 Annales de Chimie (Cachan, France), , vol. <9>13, p. 246 Journal of Physical Chemistry, , vol. 23, p. 509 Chem. Zentralbl., , vol. 91, # I p. 197

~%

Chloromethyl chloroformate Structure

Chloromethyl ch...

CAS#:22128-62-7

Literature: Journal of Chemical Physics, , vol. 17, p. 566

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Chloromethyl chloroformate Structure

Chloromethyl ch...

CAS#:22128-62-7

Literature: Journal of Chemical Physics, , vol. 21, p. 1049,1051

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Chloromethyl chloroformate Structure

Chloromethyl ch...

CAS#:22128-62-7

Literature: Kogyo Kagaku Zasshi, , vol. 51, p. 157 Chem.Abstr., , p. 5476

 Preparation


 Articles3

More Articles
Triazene drug metabolites. Part 17: Synthesis and plasma hydrolysis of acyloxymethyl carbamate derivatives of antitumour triazenes.

Bioorg. Med. Chem. 8(7) , 1719-25, (2000)

A series of 3-acyloxymethyloxycarbonyl-1-aryl-3-methyltriazenes 5 was synthesised by the sequential reaction of 1-aryl-3-methyltriazenes with (i) chloromethyl chloroformate, (ii) NaI in dry acetone, a...

Aminocarbonyloxymethyl ester prodrugs of flufenamic acid and diclofenac: suppressing the rearrangement pathway in aqueous media.

Arch. Pharm. (Weinheim) 340(1) , 32-40, (2007)

Aminocarbonyloxymethyl ester prodrugs are known to undergo rearrangement in aqueous solutions to form the corresponding N-acylamine side product via an O-->N intramolecular acyl transfer from the carb...

Water soluble cyclosporine monomethoxy poly(ethyleneglycol) conjugates as potential prodrugs.

Arch. Pharm. Res. 27(6) , 662-9, (2004)

The highly water-soluble monomethoxypoly(ethyleneglycol) (mPEG) prodrugs of cyclosporin A (CsA) were synthesized. These prodrugs were prepared by initially preparing intermediate in the form of carbon...

 Synonyms

chloromethoxycarbonyl chloride
EINECS 244-793-3
chloromethyl chlorocarbonate
chloroformic acid chloromethyl ester
Carbonochloridic acid, chloromethyl ester
Chloromethyl chloroformate
MFCD00077688
Chlorocarbonate de chlorométhyle
1-chloromethyl chloroformate
chlormethylchlorocarbonat
Chloromethyl carbonochloridate
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