Cytochalasin C

Modify Date: 2024-01-03 22:47:35

Cytochalasin C structure	Common Name	Cytochalasin C
	CAS Number	22144-76-9	Molecular Weight	507.618
	Density	1.2±0.1 g/cm3	Boiling Point	714.3±60.0 °C at 760 mmHg
	Molecular Formula	C₃₀H₃₇NO₆	Melting Point	260-264ºC
	MSDS	Chinese USA	Flash Point	385.8±32.9 °C
	Symbol	GHS06, GHS08	Signal Word	Danger

Use of Cytochalasin C

Cytochalasin C is a cell-permeable fungal toxin and induces the formation of nuclear rodlets. Cytochalasin C is 10 times less toxic in mice than is cytochalasin D[1][2][3].

Name	cytochalasin c
Synonym	More Synonyms

Description	Cytochalasin C is a cell-permeable fungal toxin and induces the formation of nuclear rodlets. Cytochalasin C is 10 times less toxic in mice than is cytochalasin D[1][2][3].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Foissner I, et al. Wide-ranging effects of eight cytochalasins and latrunculin A and B on intracellular motility and actin filament reorganization in characean internodal cells. Plant Cell Physiol. 2007 Apr;48(4):585-97. [2]. Yahara I, et al. Correlation between effects of 24 different cytochalasins on cellular structures and cellular eventsand those on actin in vitro. J Cell Biol. 1982 Jan;92(1):69-78. [3]. Trendowski M, et al. Tolerated doses in zebrafish of cytochalasins and jasplakinolide for comparison with tolerateddoses in mice in the evaluation of pre-clinical activity of microfilament-directed agents in tumormodel systems in vivo. In Vivo. 2014 Nov-Dec;28(6):1021-31.

Description

Cytochalasin C is a cell-permeable fungal toxin and induces the formation of nuclear rodlets. Cytochalasin C is 10 times less toxic in mice than is cytochalasin D[1][2][3].

Related Catalog

Research Areas >> Others

Signaling Pathways >> Others >> Others

References

[1]. Foissner I, et al. Wide-ranging effects of eight cytochalasins and latrunculin A and B on intracellular motility and actin filament reorganization in characean internodal cells. Plant Cell Physiol. 2007 Apr;48(4):585-97.

[2]. Yahara I, et al. Correlation between effects of 24 different cytochalasins on cellular structures and cellular eventsand those on actin in vitro. J Cell Biol. 1982 Jan;92(1):69-78.

[3]. Trendowski M, et al. Tolerated doses in zebrafish of cytochalasins and jasplakinolide for comparison with tolerateddoses in mice in the evaluation of pre-clinical activity of microfilament-directed agents in tumormodel systems in vivo. In Vivo. 2014 Nov-Dec;28(6):1021-31.

Density	1.2±0.1 g/cm3
Boiling Point	714.3±60.0 °C at 760 mmHg
Melting Point	260-264ºC
Molecular Formula	C₃₀H₃₇NO₆
Molecular Weight	507.618
Flash Point	385.8±32.9 °C
Exact Mass	507.262085
PSA	112.93000
LogP	2.81
Vapour Pressure	0.0±2.4 mmHg at 25°C
Index of Refraction	1.602
Storage condition	−20°C
Water Solubility	methylene chloride: 5 mg/mL, clear, colorless

Cytochalasin C MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HA5300500

CHEMICAL NAME :: (11)Cytochalasa-5,13,19-triene-1,17-dione, 21-(acetoxy)-7,18-dihydroxy-16,18-dimethyl- 10-phenyl-, (7S,13E,16S,18R,19E,21R)-

CAS REGISTRY NUMBER :: 22144-76-9

LAST UPDATED :: 199203

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 21,2268,1973

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H300 + H310 + H330-H361
Precautionary Statements	P260-P264-P280-P284-P301 + P310-P302 + P350
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T+: Very toxic;T: Toxic;
Risk Phrases	26/27/28-63
Safety Phrases	28-36/37-45
RIDADR	UN 1544 6.1/PG 2
WGK Germany	3
RTECS	HA5300500
Packaging Group	I
Hazard Class	6.1(a)

Structure of cytochalasins and cytochalasin B binding sites in human erythrocyte membranes.

Biochemistry 19 , 679, (1980)

Twenty cytochalasins were tested for binding to and for inhibition of glucose transport in human erythrocyte membrane. In this membrane three cytochalasin B (CB) binding sites have been identified. Al...

Phenotype modulation in primary cultures of rat aortic smooth muscle cells. Effects of drugs that interfere with the functions of the vacuolar system and the cytoskeleton.

Virchows Arch.,. B, Cell Pathol. 59(1) , 1-10, (1990)

The transition of adult rat aortic smooth muscle cells from a contractile to a synthetic phenotype during the first week of primary culture on a substrate of fibronectin in serum-free medium was studi...

Cytoskeleton regulates expression of genes for transforming growth factor-beta 1 and extracellular matrix proteins in dermal fibroblasts.

J. Cell Physiol. 172(2) , 192-9, (1997)

Cytoskeleton not only controls cell morphology but also regulates cell growth, migration, differentiation, and gene expression, events which are fundamental to embryogenesis, carcinogenesis, and wound...

1H-Cycloundec[d]isoindole-1,11(2H)-dione, 15-(acetyloxy)-3,3a,6,6a,9,10,12,15-octahydro-6,12-dihydroxy-4,5,10,12-tetramethyl-3-(phenylmethyl)-, (7Z,13E)-

Acétate de (7Z,13E)-3-benzyl-6,12-dihydroxy-4,5,10,12-tétraméthyl-1,11-dioxo-2,3,3a,6,6a,9,10,11,12,15-décahydro-1H-cycloundéca[d]isoindol-15-yle

EINECS 244-803-6

(7Z,13E)-3-Benzyl-6,12-dihydroxy-4,5,10,12-tetramethyl-1,11-dioxo-2,3,3a,6,6a,9,10,11,12,15-decahydro-1H-cycloundeca[d]isoindol-15-ylacetat

(7Z,13E)-3-Benzyl-6,12-dihydroxy-4,5,10,12-tetramethyl-1,11-dioxo-2,3,3a,6,6a,9,10,11,12,15-decahydro-1H-cycloundeca[d]isoindol-15-yl acetate

Cytochalasin C from Metarrhizium anisopliae

MFCD00066080

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Cytochalasin C
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Cytochalasin C
Price: ￥1078.0/1mg ￥3578.0/5mg
Purity: 97.0%
Delivery: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.