Norswertianin

Modify Date: 2024-01-11 10:24:42

Norswertianin Structure
Norswertianin structure
Common Name Norswertianin
CAS Number 22172-15-2 Molecular Weight 260.19900
Density 1.766g/cm3 Boiling Point 601.7ºC at 760mmHg
Molecular Formula C13H8O6 Melting Point N/A
MSDS N/A Flash Point 240.4ºC

 Use of Norswertianin


Norswertianin, a xanthone compound, serves as a powerful anti-glioma compound. Norswertianin induces GBM cells differentiation through oxidative stress and Akt/mTOR dependent autophagy[1].

 Names

Name norswertianin
Synonym More Synonyms

 Norswertianin Biological Activity

Description Norswertianin, a xanthone compound, serves as a powerful anti-glioma compound. Norswertianin induces GBM cells differentiation through oxidative stress and Akt/mTOR dependent autophagy[1].
Related Catalog
In Vitro Norswertianin (12.5-50 µM; 48 hours) stimulats expression of GFAP and β-tubulin in U251 cells[1]. Norswertianin (40 µM; 48 hours) causes the appearance of elongated processes in U251 cells, associated with G2/M cell cycle arrest[1]. Norswertianin (40 µM; 48 hours) exhibits an increase in intracellular acidification and LC3 conversion[1].
References

[1]. Gordana Tovilovic-Kovacevic, et al. Xanthone-rich extract from Gentiana dinarica transformed roots and its active component norswertianin induce autophagy and ROS-dependent differentiation of human glioblastoma cell line. Phytomedicine

 Chemical & Physical Properties

Density 1.766g/cm3
Boiling Point 601.7ºC at 760mmHg
Molecular Formula C13H8O6
Molecular Weight 260.19900
Flash Point 240.4ºC
Exact Mass 260.03200
PSA 111.13000
LogP 1.76860
Vapour Pressure 4.49E-15mmHg at 25°C
Index of Refraction 1.801

 Safety Information

HS Code 2932999099

 Synthetic Route

~%

Norswertianin Structure

Norswertianin

CAS#:22172-15-2

Literature: Dalal et al. Journal of the Indian Chemical Society, 1953 , vol. 30, p. 457,459, 461

 Precursor & DownStream

Precursor  1

DownStream  0

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

1,2,6,8-tetrahydroxyxanthen-9-one
1,3,7,8-Tetrahydroxyxanthone
1,2,6,8-tetrahydroxy-xanthen-9-one
1,2,6,8-Tetrahydroxyxanthone
Norswertianin
Xanthen-9-one,1,2,6,8-tetrahydroxy
1,2,6,8-Tetrahydroxy-9H-xanthen-9-one
1,2,6,8-Tetrahydroxy-xanthen-9-on
1,3,7,8-Tetrahydroxyxanthon
norswetianin
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