Spectinomycin dihydrochloride pentahydrate
Modify Date: 2026-07-01 13:11:25
Spectinomycin dihydrochloride pentahydrate structure
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Common Name | Spectinomycin dihydrochloride pentahydrate | ||
|---|---|---|---|---|
| CAS Number | 22189-32-8 | Molecular Weight | 495.348 | |
| Density | N/A | Boiling Point | 583.1ºC at 760 mmHg | |
| Molecular Formula | C14H36Cl2N2O12 | Melting Point | 205-207° (dec) | |
| MSDS | Chinese USA | Flash Point | 306.4ºC | |
Use of Spectinomycin dihydrochloride pentahydrateSpectinomycin dihydrochloride pentahydrate is a broad-spectrum aminocyclitol antibiotic that inhibits the growth of a variety of gram-positive and gram-negative organisms. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | spectinomycin hydrochloride hydrate |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Spectinomycin dihydrochloride pentahydrate is a broad-spectrum aminocyclitol antibiotic that inhibits the growth of a variety of gram-positive and gram-negative organisms. |
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| Related Catalog | |
| In Vitro | Spectinomycin selectively inhibits protein synthesis in cells and in extracts of Escherichia coli. When added to an exponentially growing culture, spectinomycin (50 μg/mL) rapidly and reversibly inhibits growth of Escherichia coli. Amino acid incorporation is slowed immediately but RNA synthesis continued. In extracts of Escherichia coli B, spectinomycin inhibits polypeptide synthesis directed either by endogenous messenger RNA or by MS-2 bacteriophage RNA. Maximum inhibition (70 to 80%) is achieved at 1 μg/mL (3 μM). [1]. Spectinomycin blocks the translocation of peptidyl-tRNAs from the A-site to the P-site by inhibiting the binding of elongation factor G to the ribosome. Spectinomycin interacts specifically with the residues G1064 and 01192 in 16S rRNA and potentially change this molecule into an inactive conformation[2]. Spectinomycin acts as a mixed noncompetitive inhibitor for the td intron RNA with a Ki of 7.2 mM. The splicing inhibition by spectinomycin is dependent on pH changes and Mg2+ concentration, indicating electrostatic interactions with the intron RNA[3]. |
| In Vivo | Renal excretion is a major elimination pathway for spectinomycin. Following IV administration, approximately 55% of the drug is excreted into the urine in unchanged form. After IV administration of 10 mg/kg spectinomycin shows a peak plasma concentration of 37.8 μg/mL and a systemic exposure (area-under the curve AUC0-∞) of 15.7 μg/mL. Following single dose intramuscular administration, the overall elimination half-life of spectinomycin is 1.2 h in cattle, 1.0 h in sheep, 1.0 h in pigs, 1.65 h in chicken and 1.85 h in humans[4]. |
| Animal Admin | Rats: Spectinomycin (10 mg/kg) is administered intravenously to rats. Serial blood samples (approx. 250 μL) are collected pre-dose, and at 0.25, 0.5, 0.75, 1.0, 1.5, 2.0, 4.0, 6.0, 8.0, 12.0, 24.0, 36.0 and 48.0 h post-dose. Plasma is separated immediately by centrifugation (10,000g for 5 min at 4°C) and stored at −80°C until analysis. Urine samples are collected at an interval of 0-6, 6-12, 12-24, 24-36 and 36-48 h post-dose and stored at −80°C until analysis[4]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Boiling Point | 583.1ºC at 760 mmHg |
|---|---|
| Melting Point | 205-207° (dec) |
| Molecular Formula | C14H36Cl2N2O12 |
| Molecular Weight | 495.348 |
| Flash Point | 306.4ºC |
| Exact Mass | 494.164520 |
| PSA | 175.66000 |
| Vapour Pressure | 5.05E-16mmHg at 25°C |
| InChIKey | UJEMGEUVWHFXGB-XYQGXRRISA-N |
| SMILES | CNC1C(O)C(NC)C2OC3(O)C(=O)CC(C)OC3OC2C1O.Cl.O |
| Storage condition | 2~8°C |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | T+ |
| Safety Phrases | 24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | WG7400000 |
| HS Code | 29419090 |
This table records publicly available preparation methods, process key points and operation references.
This table lists relevant public references with title, journal and publication metadata for this compound.
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Aminoglycoside analysis in food of animal origin with a zwitterionic stationary phase and liquid chromatography-tandem mass spectrometry.
Anal. Chim. Acta 882 , 127-39, (2015) In this study, fourteen highly polar aminoglycoside (AGs) antibiotics were selected. Various stationary phases were tested, including Obelisc R, ZIC-HILIC, BEH amide and aminopropyl. The nature of the... |
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DrugBank 3.0: a comprehensive resource for 'omics' research on drugs.
Nucleic Acids Res. 39 , D1035-41., (2011) DrugBank (http://www.drugbank.ca) is a richly annotated database of drug and drug target information. It contains extensive data on the nomenclature, ontology, chemistry, structure, function, action, ... |
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Molecular epidemiology of Neisseria gonorrhoeae isolates from Saskatchewan, Canada: utility of NG-MAST in predicting antimicrobial susceptibility regionally.
Sex. Transm. Infect. 90(4) , 297-302, (2014) To investigate the molecular epidemiology of isolates of Neisseria gonorrhoeae from Saskatchewan, Canada, using Neisseria gonorrhoeae multi antigen sequence typing (NG-MAST), and to assess association... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Identifying Sarm1 Tir Hydrolase inhibitors through NAD-Glo assay
Source: 24386
Target: N/A
External Id: Sarm1 Tir NADase inhibitors screen
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Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4513082
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Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4303805
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Name: SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
Source: ChEMBL
Target: Replicase polyprotein 1ab
External Id: CHEMBL4495582
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 4H-Pyrano[2,3-b][1,4]benzodioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-, (2S,6R,7R,8S,9S)-, hydrochloride, hydrate (1:2:5) |
| 4H-Pyrano[2,3-b][1,4]benzodioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-, (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-, hydrochloride, hydrate (1:2:5) |
| MFCD00150886 |
| spectogard |
| EINECS 244-554-3 |
| (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-4a,7,9-Trihydroxy-2-methyl-6,8-bis(methylamino)decahydro-4H-pyrano[2,3-b][1,4]benzodioxin-4-one dihydrochloride pentahydrate |
| Spectinomycin pentahydrate dihydrochloride |
| ACTINOSPECTACIN DIHYDROCHLORIDE |
| Spectinomycin HCL USP/BP |
| Spectinomycin dihydrochloride pentahydrate |
| SPECTINOMYCIN 2HCL |
| (2S,6R,7R,8S,9S)-4a,7,9-Trihydroxy-2-methyl-6,8-bis(methylamino)decahydro-4H-pyrano[2,3-b][1,4]benzodioxin-4-one dihydrochloride pentahydrate |
| Trobicin (tn) |
| SPECTINOMYCIN HCL |
| Spectinomycin hydrochloride |
| SpectinomycinHydrochloride |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the InChIKey of spectinomycin hydrochloride hydrate? |
| A: InChIKey of spectinomycin hydrochloride hydrate is UJEMGEUVWHFXGB-XYQGXRRISA-N. |
| Q: What is the English name of spectinomycin hydrochloride hydrate? |
| A: The English name of spectinomycin hydrochloride hydrate is spectinomycin hydrochloride hydrate. |
| Q: How is spectinomycin hydrochloride hydrate prepared? |
| A: Preparation method for spectinomycin hydrochloride hydrate: . |
| Q: What are the uses of spectinomycin hydrochloride hydrate? |
| A: Main uses of spectinomycin hydrochloride hydrate: Spectinomycin dihydrochloride pentahydrate is a broad-spectrum aminocyclitol antibiotic that inhibits the growth of a variety of gram-positive and gram-negative organisms. |
| Q: What is the boiling point of spectinomycin hydrochloride hydrate? |
| A: Boiling point of spectinomycin hydrochloride hydrate is 583.1ºC at 760 mmHg. |
| Q: What is the safety information for spectinomycin hydrochloride hydrate? |
| A: Safety information for spectinomycin hydrochloride hydrate: 24/25. |
| Q: What is the molecular formula of spectinomycin hydrochloride hydrate? |
| A: Molecular formula of spectinomycin hydrochloride hydrate is C14H36Cl2N2O12. |
| Q: What is the molecular weight of spectinomycin hydrochloride hydrate? |
| A: Molecular weight of spectinomycin hydrochloride hydrate is 495.348. |
| Q: What is the CAS number of spectinomycin hydrochloride hydrate? |
| A: CAS number of spectinomycin hydrochloride hydrate is 22189-32-8. |
| Q: What is the melting point of spectinomycin hydrochloride hydrate? |
| A: Melting point of spectinomycin hydrochloride hydrate is 205-207° (dec). |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |