JI130
Modify Date: 2025-10-08 17:53:02
JI130 structure
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Common Name | JI130 | ||
|---|---|---|---|---|
| CAS Number | 2234271-86-2 | Molecular Weight | 376.456 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H24N2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JI130JI130 (JI-130) is a specific Hse1 inhibitor that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone, blocks Hes1-mediated transcriptional repression; interacts with prohibitin 2 (PHB2), stabilizes PHB2's interaction with Hes1 outside the nucleus, inducing G2/M cell cycle arrest; dose-dependently reduces cell growth of the human pancreatic cancer cell line MIA PaCa-2 (IC50=49 nM); significantly reduces tumor volume in murine pancreatic tumor xenograft models. |
| Name | JI130 |
|---|
| Description | JI130 (JI-130) is a specific Hse1 inhibitor that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone, blocks Hes1-mediated transcriptional repression; interacts with prohibitin 2 (PHB2), stabilizes PHB2's interaction with Hes1 outside the nucleus, inducing G2/M cell cycle arrest; dose-dependently reduces cell growth of the human pancreatic cancer cell line MIA PaCa-2 (IC50=49 nM); significantly reduces tumor volume in murine pancreatic tumor xenograft models. |
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| References | References 1. Perron A, et al. J Biol Chem. J Biol Chem. 2018 May 25;293(21):8285-8294. View Related Products by Target Other Targets |
| Molecular Formula | C23H24N2O3 |
|---|---|
| Molecular Weight | 376.456 |
| InChIKey | BNTYDBBGNPFECO-VAWYXSNFSA-N |
| SMILES | C=CCOc1ccccc1CCNC(=O)C=Cc1c[nH]c2c(OC)cccc12 |