2234271-86-2
2234271-86-2 structure
- Name: JI130
- Chemical Name: JI130
- CAS Number: 2234271-86-2
- Molecular Formula: C23H24N2O3
- Molecular Weight: 376.456
- Catalog: Signaling Pathways Stem Cell/Wnt Notch
- Create Date: 2020-01-20 18:31:56
- Modify Date: 2024-04-05 20:33:44
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JI130 (JI-130) is a specific Hse1 inhibitor that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone, blocks Hes1-mediated transcriptional repression; interacts with prohibitin 2 (PHB2), stabilizes PHB2's interaction with Hes1 outside the nucleus, inducing G2/M cell cycle arrest; dose-dependently reduces cell growth of the human pancreatic cancer cell line MIA PaCa-2 (IC50=49 nM); significantly reduces tumor volume in murine pancreatic tumor xenograft models.
| Name | JI130 |
|---|
| Description | JI130 (JI-130) is a specific Hse1 inhibitor that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone, blocks Hes1-mediated transcriptional repression; interacts with prohibitin 2 (PHB2), stabilizes PHB2's interaction with Hes1 outside the nucleus, inducing G2/M cell cycle arrest; dose-dependently reduces cell growth of the human pancreatic cancer cell line MIA PaCa-2 (IC50=49 nM); significantly reduces tumor volume in murine pancreatic tumor xenograft models. |
|---|---|
| References | References 1. Perron A, et al. J Biol Chem. J Biol Chem. 2018 May 25;293(21):8285-8294. View Related Products by Target Other Targets |
| Molecular Formula | C23H24N2O3 |
|---|---|
| Molecular Weight | 376.456 |